Evidence map›Paper›PMID 40964309›Full record

ArticlebioRxiv : the preprint server for biology2025

Endogenous retroelements promote tolerance to dietary antigens.

Claudia A Rivera, Eduard Ansaldo, Verena M Link, Siddharth R Krishnamurthy, Ana Teijeiro, Cihan Oguz, Daniel Yong, Yasmine Belkaid

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Claudia A RiveraMetaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health. Bethesda, MD 20892.
Eduard AnsaldoMetaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health. Bethesda, MD 20892.
Verena M LinkMetaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health. Bethesda, MD 20892.
Siddharth R KrishnamurthyMetaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health. Bethesda, MD 20892.
Ana TeijeiroMetaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health. Bethesda, MD 20892.
Cihan OguzIntegrated Data Sciences Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Daniel YongMetaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health. Bethesda, MD 20892.
Yasmine BelkaidMetaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health. Bethesda, MD 20892.

Funding

Role of the microbiota in immunityZIAAI001115 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BELKAID, YASMINE · 2009 to 2025
$22.4M
cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0M
Role of Tissue-Specific Factors in the Control of ImmunityZIAAI001132 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BELKAID, YASMINE · 2011 to 2025
$6.4M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
Intramural NIH HHS ZIA AI001115Intramural NIH HHS ZIA AI001132NHLBI NIH HHS 75N92020D00005NIAID NIH HHS 75N93022D00005NIAID NIH HHS 75N93023D00005NIDA NIH HHS 75N95020D00005ORFDO NIH HHS 75N99020D00005
6 · The paper itself

Abstract

Retroelements are transposable elements that represent a significant portion of eukaryotic genomes. Here, we show that constitutive expression of endogenous retroelements play a key regulatory role in the acquisition of food tolerance. Specifically, inhibition of retroelement reverse transcription abolishes tolerance to dietary antigens and promotes allergic responses. This phenomenon is associated with impaired regulatory T cell differentiation/accumulation and altered dendritic cell tolerogenic function. Mechanistically, innate sensing of retroelement-derived cDNA via cGAS/STING within gut epithelial cells promotes a local tolerogenic milieu. Thus, within the gut, immune reactivity to retroelements act as a local tonic signal required for regulatory T cell induction and differentiation, thereby preventing allergic responses to food. Collectively, these findings uncover retroelements as key regulatory elements and essential allies in maintaining immune tolerance.

Identifiers

PMID40964309
PMCPMC12439965

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.