Evidence map›Paper›PMID 40964307›Full record

ArticlebioRxiv : the preprint server for biology2025

Inhibition of autophagy-lysosomal function exacerbates microglial and monocyte lipid metabolism reprograming and dysfunction after brain injury.

Amir A Mehrabani-Tabari, Nivedita Hegdekar, Brian R Herb, Sazia Arefin Kachi, Chinmoy Sarkar, Sagarina Thapa, Dexter Ph Nguyen, Yulemni Morel, Mehari M Weldemariam, Ludovic Muller and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Amir A Mehrabani-TabariDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Nivedita HegdekarDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Brian R HerbInstitute for Genome Sciences, University of Maryland, School of Medicine, Baltimore, MD, USA.
Sazia Arefin KachiDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.
Chinmoy SarkarDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Sagarina ThapaDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Dexter Ph NguyenDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Yulemni MorelDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.
Mehari M WeldemariamDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.
Ludovic MullerDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.
W Temple AndrewsDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.
Marcia Cortes-GutierrezInstitute for Genome Sciences, University of Maryland, School of Medicine, Baltimore, MD, USA.
Xiaoxuan FanDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
Natarajan AyithanUniversity of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center.
Olivia Pettyjohn-RobinDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Sabrina BustosDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Lacey K GreerDepartment of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Jessica T GoreDepartment of Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Maureen A KaneDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.
Seth A AmentInstitute for Genome Sciences, University of Maryland, School of Medicine, Baltimore, MD, USA.
Jace W JonesDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.
Marta M LipinskiDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.

Funding

UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANTP30CA134274 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI FEYRUZ VIRGILIA RASSOOL · 2008 to 2026
$51.0M
Dysregulation of autophagy-lysosomal function links TBI to late-onset neurodegenerationR01NS115876 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI LIPINSKI, MARTA M · 2020 to 2024
$3.1M
Regulation of LDAM by autopahgy in the aging brainR56AG081262 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI LIPINSKI, MARTA M · 2023 to 2023
$660k
Advanced components for an existing spinning disk confocal in an established core imaging facilityS10OD026698 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI BLANPIED, THOMAS A · 2019 to 2019
$274k
NCI NIH HHS P30 CA134274NIA NIH HHS R56 AG081262NIH HHS S10 OD026698NINDS NIH HHS R01 NS115876
6 · The paper itself

Abstract

CNS has an overall higher level of lipids than all tissues except adipose and contains up to 25% of total body cholesterol. Recent data demonstrate a complex crosstalk between lipid metabolism and inflammation, suggesting potential contribution of the lipid-rich brain environment to neuroinflammation. While recent data support the importance of brain lipid environment to inflammatory changes observed in age related chronic neurodegenerative diseases,

Identifiers

PMID40964307
PMCPMC12439913

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.