Evidence map›Paper›PMID 40964288›Full record

ArticlebioRxiv : the preprint server for biology2025

Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer.

Colin Sheehan, Lyndon Hu, Guillaume Cognet, Grace Croley, Thao Trang Nguyen, Anika Thomas-Toth, Darby Agovino, Patrick B Jonker, Mumina Sadullozoda, Leah M Ziolkowski and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Colin SheehanBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA, 60637.
Lyndon HuBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA, 60637.
Guillaume CognetBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA, 60637.
Grace CroleyBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA, 60637.
Thao Trang NguyenDepartment of Pediatrics, Section of Hematology/Oncology, University of Chicago, Chicago, IL, USA, 60637.
Anika Thomas-TothDepartment of Pediatrics, Section of Hematology/Oncology, University of Chicago, Chicago, IL, USA, 60637.
Darby AgovinoBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA, 60637.
Patrick B JonkerBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA, 60637.
Mumina SadullozodaBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA, 60637.
Leah M ZiolkowskiBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA, 60637.
James K MartinBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA, 60637.
Alica K BeutelDepartment of Molecular Biology and Biochemistry, University of California, Irvine, California, USA, 92697.
Ranya DanoDepartment of Pathology, University of Chicago, Chicago, IL, USA, 60637.
Mohammed A KhanDepartment of Pathology, University of Chicago, Chicago, IL, USA, 60637.
Christopher J HalbrookDepartment of Molecular Biology and Biochemistry, University of California, Irvine, California, USA, 92697.
Kay F MacleodBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA, 60637.
Christopher R WeberDepartment of Pathology, University of Chicago, Chicago, IL, USA, 60637.
James L LaBelleDepartment of Pediatrics, Section of Hematology/Oncology, University of Chicago, Chicago, IL, USA, 60637.
Alexander MuirBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA, 60637.

Funding

Multi-Disciplinary Training Grant in Cancer ResearchT32CA009594 · NCI · UNIVERSITY OF CHICAGO · PI KAY F MACLEOD, Scott A. Oakes · 1989 to 2026
$11.5M
Functions of BNIP3 in lipid metabolism in the liver and in hepatocellular carcinomaR01CA200310 · NCI · UNIVERSITY OF CHICAGO · PI KAY F MACLEOD · 2016 to 2026
$3.6M
Targeting Metabolic Crosstalk in Pancreatic CancerR37CA283575 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christopher J. Halbrook · 2024 to 2026
$1.3M
Targeting nutrient microenvironment imprinted therapy resistance in pancreatic cancerR01CA276461 · NCI · UNIVERSITY OF CHICAGO · PI Alexander Muir · 2024 to 2026
$1.2M
Role of PDK1 in pancreatic cancer cell fitness under tumor nutrient stressF31CA278362 · NCI · UNIVERSITY OF CHICAGO · PI SHEEHAN, COLIN · 2023 to 2024
$97k
NCI NIH HHS F31 CA278362NCI NIH HHS R01 CA200310NCI NIH HHS R01 CA276461NCI NIH HHS R37 CA283575NCI NIH HHS T32 CA009594
6 · The paper itself

Abstract

Cytotoxic chemotherapy remains the standard-of-care treatment for patients with pancreatic ductal adenocarcinoma (PDAC). However, chemotherapy only has modest effects at improving patient survival due to primary or rapidly acquired chemoresistance. The biological underpinnings of PDAC therapy resistance are incompletely defined, but the tumor microenvironment is known to be a major contributor to chemoresistance. We have found chemoresistance is imprinted on PDAC cells by the tumor microenvironment and persists for a period of days after PDAC cells are removed from tumors. However, PDAC chemoresistance is lost upon long term culture in standard laboratory conditions. Interestingly, culture of PDAC cells in Tumor Interstitial Fluid Medium (TIFM), a culture medium we developed to recapitulate the nutrient availability of the tumor microenvironment, maintains PDAC cells in a chemo- and targeted therapy resistant state even after long term culture

Identifiers

PMID40964288
PMCPMC12439946

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.