ArticlebioRxiv : the preprint server for biology2025
Gut Microbiota Shifts with Lifetime Duration of Oral Contraception Use.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
3 authors.
Funding
Abstract
To investigate the effects of lifetime duration of oral contraceptive (OC) use, we reanalyzed publicly available 16S rRNA sequencing data from fecal samples of OC users and non-users collected at different timepoints in the menstrual cycle. We profiled the microbial composition of subjects and identified 32 significantly differentially abundant Amplicon Sequence Variants (padj<0.05) with increasing lifetime use duration including 16 ASVs belonging to class Clostidia that decreased with longer OC use. Some Clostridia species are known to recycle estrogen; lifetime duration of OC exposure could thus influence women's health through gut microbiome composition and hormone regulation.
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Registered trials
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