Evidence map›Paper›PMID 40964260›Full record

ArticlebioRxiv : the preprint server for biology2025

Comparative Analysis of Primary and Liver Fibroblasts Reveals MET as a Potent Target in Pancreatic Cancer Metastasis.

Rima Singh, Natalie Yousefian, Walker M Allen, Cecily Anaraki, Alica K Beutel, Sabrina Calderon, Ian M Loveless, Oliver G McDonald, Jennifer P Morton, David Imagawa and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Rima SinghDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA.
Natalie YousefianDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA.
Walker M AllenDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA.
Cecily AnarakiDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA.
Alica K BeutelDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA.
Sabrina CalderonDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA.
Ian M LovelessPancreatic Cancer Center, Henry Ford Health System, Detroit, MI 48202, USA.
Oliver G McDonaldDepartment: Pathology and Laboratory Medicine, University of Miami, Miami, FL.
Jennifer P MortonCancer Research UK Scotland Institute, Glasgow G61 1BD, UK.
David ImagawaDepartment of Surgery, University of California Irvine, Orange, CA 92868, USA.
Zeljka JutricDepartment of Surgery, University of California Irvine, Orange, CA 92868, USA.
Thomas F MartinezChao Family Comprehensive Cancer Center, University of California Irvine, Orange, CA 92868, USA.
Nina G SteelePancreatic Cancer Center, Henry Ford Health System, Detroit, MI 48202, USA.
Christopher J HalbrookDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
THE EVOLUTION OF PGD ADDICTION IN HUMAN PANCREATIC CANCERR01CA222594 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Oliver Gene McDonald · 2019 to 2026
$2.5M
Targeting Metabolic Crosstalk in Pancreatic CancerR37CA283575 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christopher J. Halbrook · 2024 to 2026
$1.3M
Investigating Cellular Communication in the Tumor Microenvironment in Pancreatic CancerR00CA263154 · NCI · HENRY FORD HEALTH SYSTEM · PI STEELE, NINA G · 2022 to 2024
$862k
Disrupting macrophage metabolism to reduce immunosuppression and enhance therapy in pancreatic cancerR00CA241357 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI HALBROOK, CHRISTOPHER J. · 2020 to 2022
$778k
The Roles of a Novel Microprotein in Wound Healing and CancerK01CA249038 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI MARTINEZ, THOMAS FARID · 2021 to 2025
$688k
NCI NIH HHS K01 CA249038NCI NIH HHS P30 CA062203NCI NIH HHS R00 CA241357NCI NIH HHS R00 CA263154NCI NIH HHS R01 CA222594NCI NIH HHS R37 CA283575
6 · The paper itself

Abstract

The tumor microenvironment drives many malignant features of pancreatic ductal adenocarcinoma (PDAC). The fibroblasts within pancreatic tumors promote tissue remodeling, immune suppression, and resistance to therapy. However, the interactions between stromal populations and pancreatic cancer cells are less understood in the liver, the most frequent site of PDAC metastasis. To address this, we employ single cell transcriptomics to compare primary pancreatic vs. liver PDAC lesions. Here, we identify the expression of hepatocyte growth factor (

Identifiers

PMID40964260
PMCPMC12440037

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.