Evidence map›Paper›PMID 40964258›Full record

ArticlebioRxiv : the preprint server for biology2025

Functionally Essential and Structurally Diverse: Insights into the zebrafish Left-Right Organizer's Cilia via Optogenetic IFT88 Perturbation and Volume Electron Microscopy.

Favour Ononiwu, Melissa Mikolaj, Christopher Dell, Abdalla Wael Shamil, Kedar Narayan, Heidi Hehnly

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Favour OnoniwuDepartment of Biology, Syracuse University, USA.
Melissa MikolajCenter for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Christopher DellCenter for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Abdalla Wael ShamilDepartment of Biology, Syracuse University, USA.
Kedar NarayanCenter for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Heidi HehnlyDepartment of Biology, Syracuse University, USA.ORCID 0000-0001-6660-5254

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
The relationship between Rab11-endosomes and the centrosome during divisionR01GM127621 · NIGMS · SYRACUSE UNIVERSITY · PI HEHNLY, HEIDI · 2018 to 2022
$1.8M
Cell cycle dependent mechanisms triggering lumen formation in vivoR01GM130874 · NIGMS · SYRACUSE UNIVERSITY · PI HEHNLY, HEIDI · 2021 to 2024
$1.2M
NCI NIH HHS 75N91019D00024NIGMS NIH HHS R01 GM127621NIGMS NIH HHS R01 GM130874
6 · The paper itself

Abstract

In the zebrafish left-right organizer (LRO), the Kupffer's Vesicle (KV), cilia extend from all cells into the fluid-filled lumen, but their structural diversity and contribution to morphogenesis remain incompletely defined. We hypothesized that cilia are required for KV development and may exist in distinct structural subtypes. Using a newly engineered transgenic line (

Identifiers

PMID40964258
PMCPMC12439900

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.