Evidence map›Paper›PMID 40964256›Full record

ArticlebioRxiv : the preprint server for biology2025

Unfolded protein response signaling promotes myeloid cell production and cooperates with oncogenic mutation.

Hyunjoo Choi, Sang-Eun Jung, Hyojung Paik, Yesenia Earth, Jiye Yi, Maggie J Cox, Stephen T Oh, Yoon-A Kang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Hyunjoo ChoiDivision of Hematology, Department of Medicine, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Sang-Eun JungDivision of Hematology, Department of Medicine, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Hyojung PaikCenter for Biomedical computing, Division of National Supercomputing R&D, Korea Institute of Science and Technology Information (KISTI), and University of Science and Technology (UST), Daejeon 34141, South Korea.
Yesenia EarthDivision of Hematology, Department of Medicine, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Jiye YiDivision of Hematology, Department of Medicine, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Maggie J CoxDivision of Hematology, Department of Medicine, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Stephen T OhDivision of Hematology, Department of Medicine, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID 0000-0002-8564-5400
Yoon-A KangDivision of Hematology, Department of Medicine, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.

Funding

DYSREGULATED NFKB PATHWAY SIGNALING IN MYELOPROLIFERATIVE NEOPLASMSR01HL134952 · NHLBI · WASHINGTON UNIVERSITY · PI Stephen Oh · 2018 to 2026
$3.9M
Investigating the mechanisms of erythroid lineage commitment in hematopoietic stem and multipotent progenitor populationsK01DK120780 · NIDDK · WASHINGTON UNIVERSITY · PI KANG, YOON A · 2021 to 2023
$508k
Early myeloid lineage specification mechanisms at the top of the hematopoietic hierarchyR56DK139218 · NIDDK · WASHINGTON UNIVERSITY · PI KANG, YOON A · 2025 to 2025
$87k
NHLBI NIH HHS R01 HL134952NIDDK NIH HHS K01 DK120780NIDDK NIH HHS R56 DK139218
6 · The paper itself

Abstract

Unfolded protein response (UPR) is an evolutionally conserved adaptive mechanism that promotes protein homeostasis under endoplasmic reticulum (ER) stress. UPR signaling has numerous functions in metabolism, cancer, immunology, and neurodegenerative diseases. Recent studies also showed that UPR signaling has important roles in hematopoietic stem and progenitor cell biology. However, whether UPR signaling regulates hematopoietic lineage fate decision remains elusive. Here, we found that FcγR

Indexed as

erythropoiesisHematopoietic stem cell (HSC)Jak2V617Fmultipotent progenitor (MPP)myelopoiesispolycythemia veraunfolded protein response

Identifiers

PMID40964256
PMCPMC12439894

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.