Evidence map›Paper›PMID 40964240›Full record

ArticleJournal of asthma and allergy2025

Application of Magnetic Particle Chemiluminescence Technology to Detect Sensitization in Patients in Guangzhou, China: A Study Based on Real-World Medical Data.

Huimin Huang, Yifan Chen, Haisheng Hu, Peiyan Zheng, Wenting Luo, Yanting Fang, Yinghong Lin, Baoqing Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of asthma and allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huimin Huang *Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.
Yifan Chen *Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.
Haisheng HuDepartment of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.
Peiyan ZhengDepartment of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.ORCID 0000-0002-8795-4899
Wenting LuoDepartment of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.
Yanting FangDepartment of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.
Yinghong LinDepartment of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.
Baoqing SunDepartment of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.ORCID 0000-0002-1671-0723

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Magnetic particle chemiluminescence is a novel allergen detection technology recently introduced in clinical practice in China. This study analyzed the application of the ALLEOS assay using real-world clinical data from Guangzhou to identify regional allergen sensitization patterns. Methods: A retrospective review of 20,406 suspected allergy patients, tested for 28 specific allergens using the ALLEOS 2000 system at the First Affiliated Hospital of Guangzhou Medical University from June 2021 to January 2024. Results: The highest positive rate was observed for Dermatophagoides farinae (53.4%), followed by D. pteronyssinus (43.2%) and tropical mites (20.4%). Children showed significantly higher positivity rates for most allergens compared to adults, except for dog dander and German cockroach (P < 0.05). Among allergic diseases, children predominated in rhinitis (84.9%), while adults predominated in asthma (56.5%). In terms of severity, asthma and rhinitis patients exhibited higher sensitization levels (Class 3-6) to D. pteronyssinus (81.6% and 86.3%) and D. farinae (86.7% and 87.3%), while dermatitis patients were more sensitized to egg (19.7%) and milk (17.9%) allergens. Allergen positivity rates varied by season, with children showing significantly higher sensitization to both daisy and dandelion Conclusion: This real-world study revealed age-, disease-, and season-specific allergen sensitization patterns in southern China. Inhalant and food allergens formed three major sensitization clusters each. These findings support region- and population-specific testing strategies and may inform clinical decision-making.

Indexed as

allergendiagnostic technologymagnetic particle chemiluminescencereal-world studysIgE

Identifiers

PMID40964240
PMCPMC12439700

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