ArticleJournal of diabetes and metabolic disorders2025
Sex-specific association between serum zinc concentration and incidence of abdominal obesity: A nine-year follow-up.
Article in Journal of diabetes and metabolic disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Risk of Zinc Deficiency from Urinary Zinc Loss Induced by Antihypertensive Drugs: A Narrative Review.Biological trace element research · 2026Review
- Zinc deficiency in patients with type 2 diabetes increases risk of cardiovascular diseases: Tehran Lipid and Glucose Study.BMC cardiovascular disorders · 2026Article
- Serum Zinc Levels in Early Life and Risk of Elevated Carotid Intima-Media Thickness: An 8-Year Prospective Study.Cardiovascular toxicology · 2026Article
- Zinc Homeostasis and the Risk of Type 2 Diabetes: Complex Role of ZnT8 in Insulin and Glucagon Secretion.Current nutrition reports · 2026Review
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Authors and funding
4 authors.
Funding
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Abstract
Background: Zinc is an essential micronutrient involved in metabolic pathways, yet its association with the development of abdominal obesity (AO) is not well established. This study examined the relationship between serum zinc (SZn) concentrations and the incidence of AO, considering potential sex-specific differences. Methods: We included 1533 adult participants of the fourth phase (2009-2011) of the Tehran Lipid and Glucose Study (mean age of 43.6 ± 13.9 years, 34.3% male) and followed them up to 2018-2022. SZn concentration was measured at baseline by the flame atomic absorption spectrometry. Anthropometric measurements were done at baseline and again at three-year intervals to determine AO incidence. Univariate unrestricted regression spline (UVRS) and sex-stratified Cox proportional hazard models were used. Results: The mean (SD) of WC was 85.0 ± 6.4 cm, and the mean SZn concentration was 113 ± 46.0 µg/dL at baseline. After a median of 9.3 years follow-up, 30.1% of participants (27% of male and 31.7% of female) developed AO. A non-linear association was observed between SZn and the incidence of AO (non-linearity from the likelihood ratio test Conclusion: Our study demonstrated that a higher SZn concentration was negatively associated with the risk of developing AO in female. This finding may imply that a higher intake of zinc-rich food sources may protect against developing AO in female.
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