Evidence map›Paper›PMID 40964124›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025

[Association of Rest-Activity Rhythm With the Risk of Rheumatoid Arthritis and Effect Modification by Genetic Susceptibility].

Lele Wang, Huan Xu, Gonghua Wu, Bing Guo, Xiong Xiao, Xing Zhao, Juying Zhang

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lele Wang/ （ 610041） Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.ORCID 0000-0002-4582-7816
Huan Xu/ （ 610041） Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Gonghua Wu/ （ 610041） Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Bing Guo/ （ 610041） Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Xiong Xiao/ （ 610041） Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Xing Zhao/ （ 610041） Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Juying Zhang/ （ 610041） Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.ORCID 0000-0001-8726-142X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the association between rest-activity rhythm (RAR) and the risks of rheumatoid arthritis (RA), and to evaluate whether genetic susceptibility modifies this relationship. Methods: This prospective cohort study utilized data from the UK Biobank, including 88060 participants who did not have RA at baseline. RAR parameters (e.g., relative amplitude) were calculated using data obtained through wrist-worn accelerometers. The participants' genetic susceptibility to RA was assessed using a polygenic risk score. Cox proportional hazards models were employed to analyze the association between RAR and RA risk, with interaction terms incorporated to evaluate the effect modification by genetic susceptibility. Results: Over a median follow-up period of 7.97 years, 660 incident RA cases were identified. After adjusting for age, sex, ethnicity, educational attainment, Townsend deprivation index, drinking status, smoking status, dietary score, body mass index, and polygenic risk score for incident RA, the dose-response analysis revealed a linear relationship between the RAR-related parameters, including the average amplitude during the most active 10 h (M10), interdaily stability (IS), intradaily variability (IV), and the risk of developing RA ( Conclusion: Disrupted rest-activity rhythm is associated with an increased risk of RA, which is independent of genetic susceptibility to RA. Our findings suggest that improving rest-activity rhythm may help reduce RA risks.

Indexed as

Arthritis, RheumatoidExerciseGenetic Predisposition to DiseaseRestAdultAgedFemaleHumansMaleMiddle AgedProportional Hazards ModelsProspective StudiesRisk FactorsArthritis, RheumatoidCircadian rhythmEffect modifierEpidemiologic studiesGenetic susceptibility

Identifiers

PMID40964124
PMCPMC12439647

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.