Evidence map›Paper›PMID 40964113›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025

[YTHDF3 Regulates Macrophage Activation: Investigation of the Mechanisms Involved].

Keren Peng, Qimin Yin, Jiyu Tong

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Keren Peng（ 610041） Department of Immunology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.ORCID 0009-0005-3252-9085
Qimin Yin（ 610041） Department of Immunology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Jiyu Tong（ 610041） Department of Immunology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.ORCID 0000-0002-5453-613X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the role and the underlying mechanisms of N Methods: shRNA-mediated Results: After LPS stimulation of wild-type RAW264.7 cells, the level of pro-inflammatory factors increased and then decreased. However, the level of YTHDF3 showed the opposite trend to that of pro-inflammatory factors, suggesting that YTHDF3 might play a role in the negative regulation of macrophage activation. shRNA-mediated Conclusion: By targeting the mRNA of the key junction proteins and signaling molecules of the TLR4 pathway, YTHDF3 accelerates their rapid degradation and suppresses macrophage activation.

Indexed as

Macrophage ActivationMacrophagesRNA-Binding ProteinsAdenosineAnimalsLipopolysaccharidesMiceNF-kappa BPhagocytosisRAW 264.7 CellsRNA, Small InterferingSignal TransductionToll-Like Receptor 4AdenosineLipopolysaccharidesNF-kappa BN-methyladenosineRNA-Binding ProteinsRNA, Small InterferingTlr4 protein, mouseToll-Like Receptor 4Macrophage activationTLR4 signaling pathwayYTHDF3

Identifiers

PMID40964113
PMCPMC12439664

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.