Evidence map›Paper›PMID 40964111›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025

[Interpretation and Examples: Key Updates in SPIRIT 2025 Statement].

Zelei Dai, Renjie Zhao, Kefan Li, Yonggang Zhang, Nian Li, Wenjie Yang, Lei Liu, Lingmin Chen

Abstract readEnglish Abstract
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zelei Dai( 610041) Division of Head & Neck Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID 0000-0002-5714-9741
Renjie Zhao( 610041) Division of Head & Neck Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Kefan Li( 610041) Division of Head & Neck Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Yonggang Zhang( 610041) Division of Head & Neck Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Nian Li( 610041) Division of Head & Neck Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Wenjie Yang( 610041) Division of Head & Neck Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Lei Liu( 610041) Division of Head & Neck Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID 0000-0002-9392-7643
Lingmin Chen( 610041) Division of Head & Neck Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID 0000-0002-4542-2763

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A high-quality clinical trial protocol is the cornerstone for ensuring the scientific integrity and ethical compliance of a study. The Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) has become the international benchmark for developing clinical trial protocols since its release in 2013. To adapt to the developing trends of open science and patient-centered principles, the SPIRIT group completed a comprehensive update in 2025. While retaining its core structure, this updated guideline introduces a new open science module and incorporates several new elements, including patient and public involvement, trial monitoring, and data sharing, alongside substantial revisions of five pre-existing items. In this article, we critically examine the core revisions in SPIRIT 2025 and, through analysis of representative case studies, illustrate the practical application of the new reporting guideline in drafting trial protocols. Our goal is to to provide Chinese researchers with a valuable reference for understanding and implementing this new reporting guideline, thereby enhancing the quality and rigor of clinical trial protocols developed in the country.

Indexed as

Clinical ProtocolsClinical Trials as TopicGuidelines as TopicResearch DesignChinaHumansClinical trial protocolInterpretationReporting guidelinesSPIRIT 2025

Identifiers

PMID40964111
PMCPMC12439634

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.