Evidence map›Paper›PMID 40964109›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025

[Regulatory Role of the AKT1/AMPK Pathway in Oxidative Stress of Lens Epithelial Cells in Cataract Patients].

Yan Huang, Bingjing Lyu, Kunyuan Tang, Ke Hu

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yan Huang（ 400000） Department of Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400000, China.ORCID 0009-0007-6648-9493
Bingjing Lyu（ 400000） Department of Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400000, China.
Kunyuan Tang（ 400000） Department of Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400000, China.
Ke Hu（ 400000） Department of Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400000, China.ORCID 0009-0003-0974-3599

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To elucidate the regulatory role and the underlying molecular mechanisms of serine/threonine protein kinase 1 (AKT1) in the lens epithelium of patients with age-related cataract (ARC). Methods: 1) Differentially expressed genes in ARC were screened using bioinformatics analysis (Genecard and GEO database GSE213546), and key genes were identified through functional enrichment analysis (KEGG and GO). 2) An oxidative stress model of lens epithelial cells was established by treating HLE-B3 cells with 200 μmol/L H Results: 1) Through bioinformatics analysis, 78 differentially expressed genes were identified, with Conclusion: The oxidative stress-related gene

Indexed as

AMP-Activated Protein KinasesCataractEpithelial CellsLens, CrystallineOxidative StressProto-Oncogene Proteins c-aktCell LineHumansHydrogen PeroxideSignal TransductionAKT1 protein, humanAMP-Activated Protein KinasesHydrogen PeroxideProto-Oncogene Proteins c-aktAge-related cataractOxidative stressProtein kinaseSerine/Threonine kinase 1

Identifiers

PMID40964109
PMCPMC12439649

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.