Evidence map›Paper›PMID 40964053›Full record

ArticleFrontiers in cellular and infection microbiology2025

Gut microbiota and its metabolites promote painful diabetic peripheral neuropathy complicated with cognitive dysfunction in mice.

Junpeng Yang, Xin Lv, Ya Xu, Fenglian Huang, Xueli Yang, Xiaoyang Shi, Lingyun Zhao, Chenghong Liang, Danyu Wang, Yuanyuan Fang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Junpeng Yang *Department of Endocrinology, Henan Provincial Key Medicine Laboratory of Intestinal Microecology and Diabetes, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Xin Lv *Department of Endocrinology, Henan Provincial Key Medicine Laboratory of Intestinal Microecology and Diabetes, People's Hospital of Henan University, Zhengzhou, Henan, China.
Ya XuDepartment of Endocrinology, Henan Provincial Key Medicine Laboratory of Intestinal Microecology and Diabetes, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Fenglian HuangDepartment of Endocrinology, Henan Provincial Key Medicine Laboratory of Intestinal Microecology and Diabetes, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Xueli YangDepartment of Endocrinology, Henan Provincial Key Medicine Laboratory of Intestinal Microecology and Diabetes, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Xiaoyang ShiDepartment of Endocrinology, Henan Provincial Key Medicine Laboratory of Intestinal Microecology and Diabetes, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Lingyun ZhaoDepartment of Endocrinology, Henan Provincial Key Medicine Laboratory of Intestinal Microecology and Diabetes, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Chenghong LiangDepartment of Endocrinology, Henan Provincial Key Medicine Laboratory of Intestinal Microecology and Diabetes, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Danyu WangDepartment of Endocrinology, Henan Provincial Key Medicine Laboratory of Intestinal Microecology and Diabetes, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Yuanyuan FangDepartment of Endocrinology, Henan Provincial Key Medicine Laboratory of Intestinal Microecology and Diabetes, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Shasha TangDepartment of Endocrinology, Henan Provincial Key Medicine Laboratory of Intestinal Microecology and Diabetes, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Yalei LiuDepartment of Endocrinology, Henan Provincial Key Medicine Laboratory of Intestinal Microecology and Diabetes, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Limin WangDepartment of Endocrinology, Henan Provincial Key Medicine Laboratory of Intestinal Microecology and Diabetes, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Xinru DengDepartment of Endocrinology, Henan Provincial Key Medicine Laboratory of Intestinal Microecology and Diabetes, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Xiaobing WangDepartment of Endocrinology, Henan Provincial Key Medicine Laboratory of Intestinal Microecology and Diabetes, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Huijuan YuanDepartment of Endocrinology, Henan Provincial Key Medicine Laboratory of Intestinal Microecology and Diabetes, Henan Provincial People's Hospital, Zhengzhou, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Painful diabetic peripheral neuropathy (PDPN) is closely linked to cognitive dysfunction. The gut microbiota plays a pivotal role in the pathophysiology of diabetic neuropathy, but its contribution, along with related metabolites, to PDPN complicated by cognitive impairment remains poorly understood. This study aimed to explore the characteristics of gut microbiota and metabolites in Methods: Male homozygous Results: At 12 weeks of age, Discussion: This study highlights the intricate relationship between gut microbiota, metabolites, and both PDPN and cognitive dysfunction in

Indexed as

Cognitive DysfunctionDiabetic NeuropathiesGastrointestinal MicrobiomeAnimalsBacteriaCytokinesDisease Models, AnimalFecesHyperalgesiaMaleMiceRNA, Ribosomal, 16SCytokinesRNA, Ribosomal, 16Scognitive dysfunctiongut microbiotametabolitesmicepainful diabetic peripheral neuropathy

Identifiers

PMID40964053
PMCPMC12436300

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.