Evidence map›Paper›PMID 40964019›Full record

ArticleResearch square2025

SARS-CoV-2 infection and vaccination elicit distinct pharyngeal mucosal B cell responses in children.

Kalpana Manthiram, Qin Xu, Lihong Shi, Liya Wang, Foo Cheung, Aparna Kotekar, Galina Koroleva, Elizabeth Rice, Richard Apps, Justin Lack and 24 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

34 authors.

Kalpana ManthiramNIAID/National Institutes of Health.ORCID 0000-0001-6451-8173
Qin XuNIAID/National Institutes of Health.ORCID 0000-0003-1812-3108
Lihong ShiNational Institute of Allergy and Infectious Diseases.
Liya WangNational Institute of Allergy and Infectious Diseases.
Foo CheungTrans-NIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI).
Aparna KotekarNational Institute of Allergy and Infectious Diseases.
Galina KorolevaNIAID/National Institutes of Health.
Elizabeth RiceNational Institute of Allergy and Infectious Diseases.
Richard AppsUniversity of Cambridge.
Justin LackNational Institute of Allergy and Infectious Diseases.
Craig MartensNIH.
Can LiuYale School of Medicine.
Juraj KabatNational Institutes of Health.
Hengameh BehzadpourChildren's National Hospital.ORCID 0000-0002-0050-8336
Lela KardavaNational Institute of Allergy & Infectious Disease.ORCID 0000-0001-9135-6026
Tovah MarkowitzNIAID, NIH.
Margery SmelkinsonNIAID.ORCID 0000-0001-7777-5574
Kenneth HoehnDepartment of Biomedical Data Science, Geisel School of Medicine at Darmouth, Hanover, NH, United States.
Clarisa BucknerNational Institutes of Health.
Dominic GolecNational Institute of Allergy and Infectious Diseases.
Lorenza BellusciFood and Drug Administration.
Gabrielle GrubbsFood and Drug Administration.
Sara PourhashemiFood and Drug Administration.
Juanjie TangCBER/Food and Drug Administration.
Asya KhleborodovaNational Institute of Allergy and Infectious Diseases.
Martha KirbyNational Human Genome Research Institute.ORCID 0000-0001-7157-7964
Rachel SparksNational Institute of Allergy and Infectious Diseases.ORCID 0000-0001-8216-5084
Andrew MartinsYale University.
John TsangYale University.ORCID 0000-0003-3186-3047
Susan MoirLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health.ORCID 0000-0002-0163-6911
Surender KhuranaFood and Drug Administration.ORCID 0000-0002-0593-7965
Pamela MuddChildren's National Hospital.
Pamela SchwartzbergNIAID/National Institutes of Health.

Funding

Subjects and Samples CoreP01AI179570 · NIAID · YALE UNIVERSITY · PI Carrie L. Lucas, John S Tsang · 2025 to 2026
$9.1M
Drivers of individual variation in influenza vaccine response and protection from infectionR01AI170116 · NIAID · UNIVERSITY OF CHICAGO · PI Sarah Cobey, John S Tsang · 2022 to 2026
$7.2M
Computational mapping of human B cell migration and differentiation pathwaysR00AI159302 · NIAID · DARTMOUTH COLLEGE · PI HOEHN, KENNETH · 2023 to 2024
$498k
NIAID NIH HHS P01 AI179570NIAID NIH HHS R00 AI159302NIAID NIH HHS R01 AI170116
6 · The paper itself

Abstract

Mucosal immunity is an important correlate of protection against respiratory infections such as SARS-CoV-2. Comparing B cell responses in the upper respiratory tract following vaccination and infection may offer unique insights into mucosal immunity. Here, we characterized antigen-specific B cells in the tonsils, adenoids, and peripheral blood of children who had been infected with SARS-CoV-2 or vaccinated with SARS-CoV-2 mRNA vaccines. SARS-CoV-2-specific switched memory B cells (B

Identifiers

PMID40964019
PMCPMC12440090

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.