Evidence map›Paper›PMID 40964005›Full record

ArticleResearch square2025

Human Placental Genomic Instability Predicts Adverse Pregnancy Outcomes.

Molly Huang, Cindy Barba, Hector J Chavez, Avery S Williams, Nicholas Guo, Rhea Robertson, Emily Zhang, Arundhati Calambur, Cayla Mason, Katharine K Nelson and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Molly HuangDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Diego, La Jolla, CA, USA.
Cindy BarbaCenter for Perinatal Discovery, University of California, San Diego, La Jolla, CA, USA.
Hector J ChavezDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Diego, La Jolla, CA, USA.
Avery S WilliamsDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Diego, La Jolla, CA, USA.
Nicholas GuoDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Diego, La Jolla, CA, USA.
Rhea RobertsonDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Diego, La Jolla, CA, USA.
Emily ZhangDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Diego, La Jolla, CA, USA.
Arundhati CalamburDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Diego, La Jolla, CA, USA.
Cayla MasonDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Diego, La Jolla, CA, USA.
Katharine K NelsonDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.
Morgan MeadsDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.
Omonigho AisagbonhiCenter for Perinatal Discovery, University of California, San Diego, La Jolla, CA, USA.
Mariko HoriiCenter for Perinatal Discovery, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-4996-6792
Kathleen M FischDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-0117-7444

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
TRAINING IN REPRODUCTIVE SCIENCEST32HD007203 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PAMELA L MELLON · 1988 to 2026
$4.8M
UC San Diego Genetics Training ProgramT32GM145427 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRUCE A HAMILTON · 2022 to 2026
$2.6M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
Genomic Dissection of Placental Lesions in PreeclampsiaR21HD110893 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FISCH, KATHLEEN MARIE · 2023 to 2023
$427k
NCATS NIH HHS UL1 TR001442NICHD NIH HHS R21 HD110893NICHD NIH HHS T32 HD007203NIGMS NIH HHS K12 GM068524NIGMS NIH HHS T32 GM145427NIH HHS S10 OD026929
6 · The paper itself

Abstract

Preeclampsia is a leading cause of pregnancy-related death, accounting for over 50,000 maternal and 500,000 fetal deaths worldwide each year

Identifiers

PMID40964005
PMCPMC12440104

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.