ArticleFrontiers in pediatrics2025
The value of combined examination of serum serum heparin binding protein, tumor necrosis factor alpha, interleukin-6, platelet count, and c-reactive protein in evaluating the condition and prognosis of children with adenovirus pneumonia.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Inflammatory cytokines as biomarkers for disease severity in pediatric viral pneumonia: a systematic review and meta-analysis.Translational pediatrics · 2026Article
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Authors and funding
4 authors.
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Abstract
Background: Adenovirus pneumonia presents a significant challenge in pediatric care, with severe children leading to significant morbidity. The study evaluated the combined prognostic value of serum Heparin Binding Protein (HBP), Tumor Necrosis Factor-alpha (TNF-α), Interleukin-6 (IL-6), platelet count (PLT), and C-Reactive Protein (CRP) levels in assessing the condition and prognosis of children with adenovirus pneumonia. Methods: This retrospective study analyzed children with adenoviral pneumonia at our hospital from March 2019 to December 2024. Serum levels of HBP, TNF-α, IL-6, PLT, and CRP were measured. Participants were divided into non-severe and severe groups, and further into good and poor prognosis groups, based on clinical criteria and complications. Statistical analyses compared biomarker levels across these groups and evaluated their prognostic accuracy using receiver operating characteristic (ROC) curve analysis. Results: Elevated serum levels of HBP, TNF-α, IL-6, and CRP were significantly associated with severe adenovirus pneumonia ( Conclusion: The combination of serum HBP, TNF-α, IL-6, PLT, and CRP effectively predicted disease severity and prognosis in pediatric adenovirus pneumonia.
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