ArticleFrontiers in pediatrics2025
Adherence to recombinant human growth hormone therapy in children: influencing factors and clinical implications.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Influence of long-acting growth hormone analogs on other hypothalamic-pituitary axes: a real-world study.Journal of endocrinological investigation · 2026Article
- Can long-acting growth hormone improve adherence in pediatric growth hormone deficiency?Endocrine · 2026Review
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Authors and funding
5 authors.
Funding
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Abstract
Background: Adherence to recombinant human growth hormone (rhGH) therapy is crucial for achieving optimal outcomes in children with growth disorders. However, non-adherence remains a significant challenge, affecting treatment efficacy and patient prognosis. This study evaluates adherence rates to rhGH therapy in pediatric patients, identifies key influencing factors, and explores strategies to improve adherence. Methods: A retrospective analysis was conducted on 8,621 pediatric patients receiving rhGH therapy in China. Adherence was assessed by the proportion of prescribed doses taken, with good adherence defined as ≥86%. Factors influencing adherence were analyzed using logistic regression models, considering variables such as age, GH formulation type, treatment duration, and regional differences. Results: The overall mean adherence rate was 92%, with long-acting GH formulations associated with significantly higher adherence than daily GH injections (94% vs. 91%, Conclusion: Adherence to rhGH therapy is influenced by multiple factors, including GH formulation, age, severity of growth deficit, treatment duration, and regional disparities. Long-acting GH formulations significantly improve adherence. Tailored interventions, such as parental education, digital adherence monitoring, and personalized support programs, are essential to sustain long-term adherence and optimize treatment outcomes.
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