ArticleTetrahedron letters2024
Oxidative Construction of Unusual Indole-Derived Intermediates en Route to Conodusine A.
Article in Tetrahedron letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Disrupting Substance Use Disorder: The Chemistry of Iboga Alkaloids.European journal of organic chemistry · 2024Article
- Total Synthesis of Tabernanthine and Ibogaline: Rapid Access to Nosyl Tryptamines.European journal of organic chemistry · 2024Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
We describe several approaches to the tricyclic core of conodusine A. Synthesis of a macrocyclic alkene set the stage for 1,2-olefin difunctionalization with conodusine's pendent amine. Unanticipated reactivity of an unusually labile indole mitigated the desired olefin manipulation. Efforts to pre-install the oxidation state at C19 before macrocyclic ring closure were met with unexpected results. Additionally, late stage allylic oxidation of the complete carbon skeleton of Conodusine was fraught with unforeseen challenges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.