Evidence map›Paper›PMID 40963941›Full record

SynthesisFrontiers in neurology2025

Optimal training strategy for body weight support treadmill training to enhance lower limb motor function and activity of daily living in persons with stroke: a systematic review and meta-analysis of randomized controlled trials.

Yan Shi, Junying Liu, Xinxin Zhang

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yan ShiDepartment of Exercise Science, School of Physical Education, Shaanxi Normal University, Xi'an, China.
Junying LiuDepartment of Exercise Science, School of Physical Education, Shaanxi Normal University, Xi'an, China.
Xinxin ZhangDepartment of Exercise Science, School of Physical Education, Shaanxi Normal University, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This meta-analysis aimed to investigate the effect of body weight support treadmill training (BWSTT) on lower limb motor function and daily living activities in a person with a stroke while also exploring the optimal training strategy. Methods: Six databases (PubMed, Web of Science, The Cochrane Library, CNKI, Wanfang, and SinoMed) were searched up to August 2025. Randomized controlled trials involving persons with stroke, BWSTT, and outcomes measured by the Fugl-Meyer assessment of lower extremity and Barthel Index scores were included. The risk of bias was assessed using the RoB-2 tool of the Cochrane Collaboration, and the certainty of evidence was assessed using the GRADE tool. Results: 25 studies with 1,749 people with stroke were incorporated into the meta-analysis. The meta-analysis demonstrated that BWSTT significantly outperformed the control group in improving both the Fugl-Meyer lower extremity score (MD = 4.80, 95% CI: 2.90-6.71, Conclusion: BWSTT improved the lower limb function and daily activities of persons with stroke, with optimal outcomes at disease duration of 3-6 months or undergoing interventions for 4-8 weeks, and more than 30% of the maximum body weight support level or using a gait speed exceeding 0.2 m/s. It is unclear whether persons with disease durations of 3-6 months could achieve the same outcomes as those undergoing 4-8 weeks of intervention. The very low quality of evidence suggests that the conclusions require further validation through high-quality randomized controlled trials. Systematic review registration: http://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42023486562.

Indexed as

activity of daily livingbody weight support treadmill traininglower limb motor functionmeta-analysisstroke

Identifiers

PMID40963941
PMCPMC12436104

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.