ArticleFrontiers in neurology2025
Exploring potential mechanistic aspects of "Biaoben acupoint" acupuncture for lumbar disc herniation using 4D proteomics.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Efficacy and Safety of CT-Verified Deep Needling at the Foramen Acupoint for Lumbar Disc Herniation: A Randomized Controlled Trial.Pain research & management · 2026Trial
- Circulating soluble CXCR4 fails to differentiate subtypes of primary aldosteronism.Journal of the Endocrine Society · 2026Article
- Data Mining-Based Analysis of Acupoint Selection Patterns in Acupuncture Treatment for Lumbar Disc Herniation.Journal of pain research · 2026Review
- Interleukin-Mediated Inflammatory Pathways and Nerve Injury in Lumbar Disc Herniation: A Narrative Review.International journal of general medicine · 2026Review
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Authors and funding
11 authors.
Funding
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Abstract
Objective: To investigate the mechanism of action of "Biaoben acupoint" acupuncture in treating lumbar disc herniation (LDH) by identifying differentially expressed plasma proteins (DEPs) using timsTOF Pro-based 4D data-independent acquisition (DIA) proteomics and correlating them with clinical indicators. Methods: This study enrolled 10 healthy individuals (H group) and 10 patients diagnosed with LDH. Plasma samples were collected from LDH patients both before treatment (LDH group) and after three weeks of "Biaoben acupoint" acupuncture treatment (Acu group). Clinical outcomes, including Visual Analogue Scale (VAS) for pain, Oswestry Disability Index (ODI) for lumbar function, and Japanese Orthopaedic Association (JOA) score for neurological status, were assessed before and after treatment. Plasma samples were collected for proteomic analysis and key core proteins were further validated by ELISA. Results: Acupuncture treatment significantly improved VAS, ODI, and JOA scores in the Acu group compared to the LDH group ( Conclusion: "Biaoben acupoint" acupuncture likely exerts its therapeutic effects by modulating multiple biological pathways related to inflammatory/immune responses, cytoskeleton organization, cell structure/adhesion, and tissue repair, thereby improving pain, lumbar function, and neurological deficits in LDH patients. Proteins such as CXCL12, ACTN1, CXCR4, and CCN2 are potential key mediators of these therapeutic effects.
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