Evidence map›Paper›PMID 40963931›Full record

ArticleTheranostics2025

Molecular and functional MRI enables detection of cardiac fibrosis and evaluation of treatment response after

Konstantina Amoiradaki, Mateusz Tomczyk, Xiaoying Wang, Gastão Cruz, Carlos Velasco, Lorena Zentilin, Francesca Bortolotti, Claudia Prieto, René M Botnar, Mauro Giacca and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Konstantina AmoiradakiSchool of Biomedical Engineering and Imaging Sciences, King's College London, Research Department of Cardiovascular Imaging, 4 th Floor, Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.
Mateusz TomczykSchool of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London SE5 9NU, UK.
Xiaoying WangSchool of Biomedical Engineering and Imaging Sciences, King's College London, Research Department of Cardiovascular Imaging, 4 th Floor, Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.
Gastão CruzSchool of Biomedical Engineering and Imaging Sciences, King's College London, Research Department of Cardiovascular Imaging, 4 th Floor, Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.
Carlos VelascoSchool of Biomedical Engineering and Imaging Sciences, King's College London, Research Department of Cardiovascular Imaging, 4 th Floor, Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.
Lorena ZentilinMolecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), 34139 Trieste, Italy.
Francesca BortolottiMolecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), 34139 Trieste, Italy.
Claudia PrietoSchool of Biomedical Engineering and Imaging Sciences, King's College London, Research Department of Cardiovascular Imaging, 4 th Floor, Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.
René M BotnarSchool of Biomedical Engineering and Imaging Sciences, King's College London, Research Department of Cardiovascular Imaging, 4 th Floor, Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.
Mauro GiaccaSchool of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London SE5 9NU, UK.
Alkystis PhinikaridouSchool of Biomedical Engineering and Imaging Sciences, King's College London, Research Department of Cardiovascular Imaging, 4 th Floor, Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac fibrosis (CF), characterised by accumulation of collagen and elastin, drives adverse cardiac remodelling and heart failure after myocardial infarction (MI). Currently, there are no non-invasive imaging methods to sensitively and directly assess CF and evaluate treatment response and no regenerative therapies for patients with MI. We hypothesised that functional and molecular magnetic resonance imaging (MRI) of collagen and elastin can detect and measure cardiac fibrosis and changes in response to

Indexed as

FibrosisGenetic TherapyIntercellular Signaling Peptides and ProteinsMagnetic Resonance ImagingMyocardial InfarctionAnimalsCollagenDependovirusDisease Models, AnimalElastinGenetic VectorsMaleMiceMice, Inbred C57BLMyocardiumTreatment OutcomeCollagenElastinIntercellular Signaling Peptides and Proteinscardiac fibrosiselastingene-therapymolecular MRI imagingmyocardial infarctiontreatment responsetype 1 collagen

Identifiers

PMID40963931
PMCPMC12439134

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.