Evidence map›Paper›PMID 40963908›Full record

ArticleTheranostics2025

Neutrophil extracellular traps induce endothelial damage and exacerbate vasospasm in traumatic brain injury.

Jinchao Wang, Lei Li, Jianye Xu, Dilmurat Gheyret, Kaiji Li, Xu Zhang, Haoran Jia, Ye Tian, Xiao Liu, Shenghui Li and 15 more

Abstract read
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Jinchao WangDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Lei LiDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Jianye XuDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, China.
Dilmurat GheyretDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Kaiji LiSpine Center, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Xu ZhangDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Haoran JiaDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Ye TianDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Xiao LiuNational Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System, Tianjin Key Laboratory of Injuries, Variations, and Regeneration of Nervous System, Tianjin Neurological Institute, Ministry of Education, Tianjin, China.
Shenghui LiNational Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System, Tianjin Key Laboratory of Injuries, Variations, and Regeneration of Nervous System, Tianjin Neurological Institute, Ministry of Education, Tianjin, China.
Guili YangNational Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System, Tianjin Key Laboratory of Injuries, Variations, and Regeneration of Nervous System, Tianjin Neurological Institute, Ministry of Education, Tianjin, China.
Yalong GaoDepartment of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China.
Ruilong PengDepartment of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China.
Huajie LiuDepartment of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong First Medical University, Jinan, China.
Bin LiuDepartment of Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong First Medical University, Jinan, China.
Jianfeng ZhuangDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, China.
Cong WangDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Xin ChenDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Yafan LiuDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Bo ChenDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Chuan HuangDepartment of Physical Medicine and Rehabilitation, Tianjin Medical University General Hospital, 154 Anshan Rd, District Heping, Tianjin, China.
Yuhan LiDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Xin ChenDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Jianning ZhangDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Shu ZhangDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral vasospasm (CVS) critically exacerbates secondary brain injury following traumatic brain injury (TBI). Understanding the underlying mechanisms is essential for developing targeted interventions.

Indexed as

Brain Injuries, TraumaticEndothelial CellsExtracellular TrapsNeutrophilsVasospasm, IntracranialAnimalsBlood-Brain BarrierDisease Models, AnimalHumansMaleMiceMice, Inbred C57BLMice, KnockoutNF-kappa BToll-Like Receptor 4Triggering Receptor Expressed on Myeloid Cells-1NF-kappa BTlr4 protein, mouseToll-Like Receptor 4Triggering Receptor Expressed on Myeloid Cells-1Endothelial dysfunctionNeutrophil extracellular trapsTraumatic brain injuryTREM1Vascular spasm

Identifiers

PMID40963908
PMCPMC12439479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.