Evidence map›Paper›PMID 40963881›Full record

ArticleAperture neuro2025

Lead-Tutor: An Open-Access Educational Resource for Deep Brain Stimulation Electrode Localizations.

Savir Madan, Lauren A Hart, Ningfei Li, Till A Dembek, Konstantin Butenko, Garance M Meyer, Nanditha Rajamani, Lukas Goede, Bahne Hendrik Bahners, Julianna Pijar and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aperture neuro, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Savir MadanCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Lauren A HartCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ningfei LiMovement Disorder and Neuromodulation Unit, Department of Neurology, Charité -Universitätsmedizin Berlin, Berlin, Germany.
Till A DembekCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Konstantin ButenkoCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Garance M MeyerCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Nanditha RajamaniCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Lukas GoedeCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Bahne Hendrik BahnersCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Julianna PijarCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Patricia ZvarovaMovement Disorder and Neuromodulation Unit, Department of Neurology, Charité -Universitätsmedizin Berlin, Berlin, Germany.
Ilkem Aysu SahinMovement Disorder and Neuromodulation Unit, Department of Neurology, Charité -Universitätsmedizin Berlin, Berlin, Germany.
Helen FriedrichCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ignacio Aracil-BolanosCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Melissa ChuaCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Clemens NeudorferCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Jordy TasserieCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Andreas HornCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.

Funding

BRAIN CONNECTS: The center for Large-scale Imaging of Neural Circuits (LINC)UM1NS132358 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Suzanne N Haber, Elizabeth M. C. Hillman · 2023 to 2026
$17.5M
Using human brain connectivity to identify the causal neuroanatomical substrate of depression symptomsR01MH113929 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2017 to 2026
$6.9M
Toward Connectomic Deep Brain Stimulation in Obsessive Compulsive DisorderR01MH130666 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2022 to 2026
$3.9M
Using Brain Lesions and Deep Brain Stimulation to Identify an Epilepsy CircuitR01NS127892 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2022 to 2026
$3.4M
NIMH NIH HHS R01 MH113929NIMH NIH HHS R01 MH130666NINDS NIH HHS R01 NS127892NINDS NIH HHS UM1 NS132358
6 · The paper itself

Abstract

Deep Brain Stimulation (DBS) is a neurosurgical procedure that involves implanting electrodes into specific brain regions to treat brain disorders. Accurate reconstruction of electrode placement is crucial for treatment optimization. Several systems, such as Lead-DBS, have been developed to reconstruct DBS electrodes, and typically require expert user input. However, open DBS datasets with localized electrodes are not available, posing a challenge to train research personnel on accurate use of these methods. In this paper, we introduce Lead-Tutor, an open-access educational resource that combines an imaging dataset of anonymized DBS cases with a software tool for self-teaching. This resource includes a dataset of pre- and post-operative magnetic resonance imaging (MRI) and computed tomography (CT) scans from ten patients with DBS implants. Along with this dataset, we provide a means for users to practice and enhance their electrode localization skills through the Lead-DBS pipeline. Aimed at new scientists in the DBS field, Lead-Tutor is a comprehensive resource available within Lead-DBS that promotes open science and education for enhanced reproducibility and potential clinical applications.

Identifiers

PMID40963881
PMCPMC12439812

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.