Evidence map›Paper›PMID 40963755›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Post-traumatic stress disorder and REM-sleep behavior disorder: exploring genetic associations and causal links.

Morvarid Ghamgosar Shahkhali, Lang Liu, Mohammad H Ghamgosar Shahkhali, Eric Yu, Farnaz Asayesh, Jamil Ahmad, Meron Teferra, Isabelle Arnulf, Pauline Dodet, Yo-El Ju and 53 more

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Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

63 authors.

Morvarid Ghamgosar ShahkhaliThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada.
Lang LiuThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada.
Mohammad H Ghamgosar ShahkhaliDepartment of Computer Engineering, Ahrar Institute of Technology and Higher Education, Rasht, Guilan, Iran.
Eric YuThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada.
Farnaz AsayeshThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada.
Jamil AhmadThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada.
Meron TeferraThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada.
Isabelle ArnulfSleep Clinic, Pitié Salpêtrière hospital, APHP-Sorbonne University and Paris Brain institute, France.
Pauline DodetSleep Clinic, Pitié Salpêtrière hospital, APHP-Sorbonne University and Paris Brain institute, France.
Yo-El JuDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Michele T M HuNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Jacques Y MontplaisirCentre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada.
Jean-François GagnonCentre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada.
Alex DesautelsCentre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada.
Abubaker IbrahimDepartment of Neurology, Sleep Disorders Clinic, Medical University of Innsbruck, Innsbruck, Austria.
Ambra StefaniDepartment of Neurology, Sleep Disorders Clinic, Medical University of Innsbruck, Innsbruck, Austria.
Birgit HöglDepartment of Neurology, Sleep Disorders Clinic, Medical University of Innsbruck, Innsbruck, Austria.
Merve Akrtan-SüzgünDepartment of Neurology, Sleep Disorders Clinic, Medical University of Innsbruck, Innsbruck, Austria.
Alex IranzoNeurology Service, Sleep Centre, Hospital Clínic Barcelona, Universitat de Barcelona, IDIBAPS, CIBERNED: CB06/05/0018-ISCIII, Barcelona, Spain.
Mónica SerradellNeurology Service, Sleep Centre, Hospital Clínic Barcelona, Universitat de Barcelona, IDIBAPS, CIBERNED: CB06/05/0018-ISCIII, Barcelona, Spain.
Angelica MontiniNeurology Service, Sleep Centre, Hospital Clínic Barcelona, Universitat de Barcelona, IDIBAPS, CIBERNED: CB06/05/0018-ISCIII, Barcelona, Spain.
Gerard MayaNeurology Service, Sleep Centre, Hospital Clínic Barcelona, Universitat de Barcelona, IDIBAPS, CIBERNED: CB06/05/0018-ISCIII, Barcelona, Spain.
Carles GaigNeurology Service, Sleep Centre, Hospital Clínic Barcelona, Universitat de Barcelona, IDIBAPS, CIBERNED: CB06/05/0018-ISCIII, Barcelona, Spain.
Gian Luigi GigliDepartment of Head, Neck and Neurosciences, Clinical Neurology Unit, University Hospital of Udine, Udine, Italy.
Mariarosaria ValenteDepartment of Head, Neck and Neurosciences, Clinical Neurology Unit, University Hospital of Udine, Udine, Italy.
Francesco JanesDepartment of Head, Neck and Neurosciences, Clinical Neurology Unit, University Hospital of Udine, Udine, Italy.
Andrea BernardiniDepartment of Head, Neck and Neurosciences, Clinical Neurology Unit, University Hospital of Udine, Udine, Italy.
Yves DauvilliersNational Reference Centre for Orphan Diseases, Narcolepsy - Rare hypersomnias, Sleep Unit, Department of Neurology, CHU Montpellier, Institute for Neurosciences of Montpellier INM, Univ Montpellier, INSERM, Montpellier, France.
Karel SonkaDepartment of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic.
David KemlinkDepartment of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic.
Petr DusekDepartment of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic.
Michael SommerauerDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Gültekin TamgüneyInstitute of Biological Information Processing - Structural Biochemistry (IBI-7), Forschungszentrum Jülich, Jülich, Germany.
Michela FigorilliDepartment of Medical Sciences and Public Health, Sleep Disorder Research Center, University of Cagliari, Cagliari, Italy.
Monica PulighedduDepartment of Medical Sciences and Public Health, Sleep Disorder Research Center, University of Cagliari, Cagliari, Italy.
Valerie Cochen De CockSleep and Neurology Unit, Beau Soleil Clinic, Montpellier, France.
Wolfgang OertelDepartment of Neurology, Philipps-University, Marburg, Germany.
Annette JanzenDepartment of Neurology, Philipps-University, Marburg, Germany.
Elena AntelmiAOVR, Verona, Italy.
Brit MollenhauerDepartment of Neurology, University Medical Centre Göttingen, Göttingen, Germany.
Claudia TrenkwalderDepartment of Neurology, University Medical Centre Göttingen, Göttingen, Germany.
Friederike Sixel-DoringDepartment of Neurology, Philipps-University, Marburg, Germany.
Michele TerzaghiDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Giuseppe FiamingoCentre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada.
Matej SkorvanekDepartment of Neurology, Faculty of Medicine, P. J. Safarik University, Kosice, Slovakia.
Kristina KulcsarovaDepartment of Neurology, Faculty of Medicine, P. J. Safarik University, Kosice, Slovakia.
Beatriz AbrilSleep disorder Unit, Carémeau Hospital, University Hospital of Nîmes, Nîmes, France.
Christelle Charley MonacaDepartment of Clinical Neurophysiology and Sleep Center, University Lille North of France, CHU Lille, Lille, France.
Luigi Ferini-StrambiDepartment of Neurological Sciences, Università Vita-Salute San Raffaele, Milan, Italy.
Jitka BuškováDepartment of Sleep Medicine, National Institute of Mental Health, Klecany, Czech Republic.
Beatrice OrsoDepartment of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy.
Pietro MattioliDepartment of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy.
Dario ArnaldiDepartment of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy.
Femke DijkstraLaboratory for Sleep Disorders, St. Dimpna Regional Hospital, Geel, Belgium.
Mineke ViaeneLaboratory for Sleep Disorders, St. Dimpna Regional Hospital, Geel, Belgium.
Bradley F BoeveDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Owen A RossDepartments of Neuroscience and Clinical Genomics, Mayo Clinic, Jacksonville, FL, USA.
Guy A RouleauThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada.
Lee E NeilsonDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.
Jonathan E ElliottDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.
Miranda M LimDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.
Ronald B PostumaThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada.
Ziv Gan-OrThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada.

Funding

Project: Predicting PhenoconversionU19AG071754 · NIA · WASHINGTON UNIVERSITY · PI KEJAL KANTARCI · 2021 to 2026
$41.2M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9M
Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2019 to 2026
$33.5M
Research Education ComponentP30AG066518 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Zachary Beattie · 2020 to 2026
$28.6M
iPSCs to study Diversity in Alzheimers disease and Alzheimers disease-related dementias (iDA)ZIAAG000546 · NIA · NATIONAL INSTITUTE ON AGING · PI COOKSON, MARK · 2022 to 2025
$12.5M
Neuroprotective Treatment Trial Planning in REM Sleep Behavior DisorderR34AG056639 · NIA · WASHINGTON UNIVERSITY · PI BOEVE, BRADLEY F, JU, YO-EL S · 2018 to 2019
$1.2M
Intramural NIH HHS ZIA AG000546NIA NIH HHS P30 AG062677NIA NIH HHS P30 AG066518NIA NIH HHS P50 AG016574NIA NIH HHS R34 AG056639NIA NIH HHS U19 AG071754RRD VA I01 RX004822
6 · The paper itself

Abstract

Objective: To explore potential genetic and/or causal associations between Post-Traumatic Stress Disorder and neurodegeneration-related isolated/idiopathic rapid-eye-movement sleep behavior disorder. Methods: We conducted polygenic risk score, genetic correlation, and Mendelian randomization analyses using the latest genome-wide association studies summary statistics and individual genotyping data. Next, a blinded observer examined dopamine transporter imaging binding status-a marker of neurodegeneration-in patients with isolated/idiopathic rapid-eye movement sleep behavior disorder, with (N = 6) and without Post-Traumatic Stress Disorder (N = 32). Results: Polygenic risk scores for Post-Traumatic Stress Disorder were associated with isolated/idiopathic rapid-eye-movement sleep behavior disorder, with each standard deviation increase linked to 14.7% higher odds (odds ratio = 1.15, 95% confidence interval: 1.04 to 1.26, p = 0.005). However, genetic correlation was weak, and Mendelian randomization did not support a potential causal relationship. The proportion of individuals with abnormal dopamine transporter imaging binding status was significantly higher in the Post-Traumatic Stress Disorder group compared to those without the disorder (p=0.01, X Interpretation: Polygenic risk scores analysis identified an association between Post-Traumatic Stress Disorder and neurodegeneration-related isolated/idiopathic rapid-eye-movement sleep behavior disorder, consistent with the result from the small exploratory substudy. The lack of strong genetic correlation or causation may reflect limited sample size. Further research with larger and more diverse cohorts is crucial to clarify the genetic, biological and physiological mechanisms underlying this association.

Identifiers

PMID40963755
PMCPMC12440045

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.