ArticlemedRxiv : the preprint server for health sciences2025
Intermittent Hypoxemia and Brain Injury Biomarker S100B in Preterm Infants.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Intermittent hypoxemia (IH) is common in preterm infants and linked to brain injury. S100B is a glial-derived protein that rises early after neural injury and can be measured noninvasively in urine. We evaluated the relationship between IH burden and urinary S100B in preterm infants ≤32 weeks' gestation. Methods: Preterm infants ≤32 weeks' gestation were prospectively enrolled. Oxygen saturation was continuously monitored, and IH profiles were quantified using validated algorithms. Urine S100B was measured by ultrasensitive immunoassay. Infants with severe intraventricular hemorrhage were excluded. Spearman correlations examined associations between IH metrics and urinary S100B, overall and by gestational age subgroups. Results: Twenty-one infants contributed 53 urine samples. Higher urinary S100B correlated with greater IH frequency, percent time in hypoxemia, longer event duration, and lower nadir saturations (all p <0.05). Short events showed the strongest correlations for frequency ( Conclusions: Urinary S100B increases with IH burden, with patterns varying by gestational age and event duration. Urinary S100B may provide an early, noninvasive biomarker of IH-related brain injury in preterm infants.
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