Evidence map›Paper›PMID 40963729›Full record

ArticleJournal of clinical biochemistry and nutrition2025

Effectiveness of the serum ratio of l-cysteine to glutathione for the prediction of cardiovascular events.

Yuki Ishinoda, Nobuyuki Masaki, Yasuhiro Hitomi, Ryota Nakazawa, Akira Taruoka, Akane Kawai, Midori Iwashita, Yasuo Ido, Yusuke Yumita, Kazuki Kagami and 6 more

Abstract read
In one paragraph

Article in Journal of clinical biochemistry and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yuki IshinodaDepartment of Nephrology and Endocrinology, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi, Saitama 359-8513, Japan.
Nobuyuki MasakiDepartment of Intensive Care Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi, Saitama 359-8513, Japan.
Yasuhiro HitomiDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi, Saitama 359-8513, Japan.
Ryota NakazawaDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi, Saitama 359-8513, Japan.
Akira TaruokaDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi, Saitama 359-8513, Japan.
Akane KawaiDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi, Saitama 359-8513, Japan.
Midori IwashitaDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi, Saitama 359-8513, Japan.
Yasuo IdoDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi, Saitama 359-8513, Japan.
Yusuke YumitaDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi, Saitama 359-8513, Japan.
Kazuki KagamiDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi, Saitama 359-8513, Japan.
Risako YasudaDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi, Saitama 359-8513, Japan.
Yukinori IkegamiDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi, Saitama 359-8513, Japan.
Takumi ToyaDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi, Saitama 359-8513, Japan.
Yuji NagatomoDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi, Saitama 359-8513, Japan.
Bonpei TakaseDepartment of Intensive Care Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi, Saitama 359-8513, Japan.
Takeshi AdachiDepartment of Cardiology, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi, Saitama 359-8513, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aminothiols play an important role in the antioxidant defense system. Their serum profile may be a predictor of prognosis and cardiovascular events. This study followed-up 262 patients (202 men; age, 65 ± 13 years) who had been treated for cardiovascular disease. The patients were divided into two groups by the median total l-cysteine to total glutathione (tCySH/tGSH) ratio in serum at enrollment. There were 32 (11%) all-cause deaths, 20 (8%) cardiovascular deaths, and 32 (12%) major cardiovascular events in 5.5 ± 3.2 years. Twenty-nine (11%) patients were hospitalized for heart failure. The high tCySH/tGSH ratio group (≥80.70) had a higher incidence of all-cause death than the low tCySH/tGSH ratio group (<80.70; log-rank test,

Indexed as

aminothiolscardiovascular diseasecardiovascular eventglutathionel-cysteine

Identifiers

PMID40963729
PMCPMC12440669

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.