ArticleJournal of clinical biochemistry and nutrition2025
Regulating effect of serum selenium on diabetic kidney disease related all-cause mortality: evidence from NHANES database.
Article in Journal of clinical biochemistry and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
To explore the interaction between Diabetic kidney disease (DKD) and serum selenium (Se) on mortality from all-cause. Information from the National Health and Nutrition Examination Surveys database (2011-2016) were retrospectively extracted for this cohort study. Associations of DKD and serum Se level with all-cause mortality were evaluated by weighted uni- and multi-variate COX regression analyses, with 95% confidence intervals (CIs) and hazard ratios (HRs). The interaction was measured by attributable proportion of interaction (APAB), relative excess risk due to interaction (RERI), synergy index (S) and 95% CIs. Among 793 adult patients, 98 died from all cause. DKD was linked to an increased all-cause mortality risk [HR = 3.69, 95% CI (1.75-7.81)], while elevated serum Se levels were linked to a decreased all-cause mortality risk [HR = 0.49, 95% CI (0.28-0.86)], after adjusting for co-variables including age, education level, physical activity (PA), CVD, WBC, neutrophil, HB, ALB, and Zn. Additionally, there was a potential antagonistic interaction between DKD and serum Se level on all-cause mortality, with the S value of 0.228. Se may play a protective role in all-cause mortality related to DKD in patients with DM, but this interaction effect needed further exploration.
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