Evidence map›Paper›PMID 40963710›Full record

ArticleIEEE journal of solid-state circuits2024

Monolithic Electronic-Biophotonic System-on-Chip for Label-Free Real-Time Molecular Sensing.

Christos Adamopoulos, Hyeong-Seok Oh, Sidney Buchbinder, Panagiotis Zarkos, Pavan Bhargava, Asmaysinh Gharia, Ali Niknejad, Mekhail Anwar, Vladimir Stojanović

Abstract read
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In one paragraph

Article in IEEE journal of solid-state circuits, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christos AdamopoulosDepartment of Electrical Engineering and Computer Science, University of California at Berkeley, Berkeley, CA 94720 USA.
Hyeong-Seok OhDepartment of Electrical Engineering and Computer Science, University of California at Berkeley, Berkeley, CA 94720 USA.
Sidney BuchbinderDepartment of Electrical Engineering and Computer Science, University of California at Berkeley, Berkeley, CA 94720 USA.
Panagiotis ZarkosDepartment of Electrical Engineering and Computer Science, University of California at Berkeley, Berkeley, CA 94720 USA.
Pavan BhargavaDepartment of Electrical Engineering and Computer Science, University of California at Berkeley, Berkeley, CA 94720 USA.
Asmaysinh GhariaDepartment of Radiation Oncology, University of California at San Francisco, San Francisco, CA 94158.
Ali NiknejadDepartment of Electrical Engineering and Computer Science, University of California at Berkeley, Berkeley, CA 94720 USA.
Mekhail AnwarDepartment of Radiation Oncology, University of California at San Francisco, San Francisco, CA 94158.
Vladimir StojanovićDepartment of Electrical Engineering and Computer Science, University of California at Berkeley, Berkeley, CA 94720 USA.

Funding

UC BRAID Center for Accelerated Innovation COVID-19 diagnostic project developmentU54HL119893 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PALAZZOLO, MICHAEL J · 2013 to 2020
$18.3M
NHLBI NIH HHS U54 HL119893
6 · The paper itself

Abstract

Label-free miniaturized optical sensors can have a tremendous impact on highly sensitive and scalable Point-of-Care (PoC) diagnostics by monitoring in real-time molecular interactions without any labels. However, current biophotonic platforms are limited by complex optical and external readout equipment, precluding their use in a PoC setting. In this work, we address this challenge by developing a first-of-its-kind fully integrated electronic-photonic label-free molecular sensor utilizing micro-ring resonators (MRRs) co-integrated with on-chip electronics in a high-volume advanced electronic process. In particular, we present an arrayed electronic-photonic system-on-chip (EPSoC) in GlobalFoundries (GF) 45-nm RFSOI with sixty 5-um radius MRRs connected to on-chip receivers, approaching an idealized limit of detection (LoD) equivalent to a single 140-nm viral particle. To further enhance the LoD, we propose a dual-ring phase-based sensing architecture, boosting the system's sensitivity by 3.7

Indexed as

BiosensingCMOSelectronic-photoniclabel-freelab-on-chipmicroring resonatormolecular sensingpoint-of-carereal-timesystem-on-chip

Identifiers

PMID40963710
PMCPMC12439853

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.