Evidence map›Paper›PMID 40963615›Full record

ArticleFrontiers in immunology2025

Dendritic cells in the human vaginal mucosa can direct CD4

HyeMee Joo, Laurie Baert, Agnes Yang, Dorothee Duluc, Johnny Yi, SangKon Oh

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

HyeMee JooDepartment of Immunology, Mayo Clinic, Scottsdale, AZ, United States.
Laurie BaertDepartment of Immunology, Mayo Clinic, Scottsdale, AZ, United States.
Agnes YangDepartment of Immunology, Mayo Clinic, Scottsdale, AZ, United States.
Dorothee DulucImmunoconcept, CNRS UMR 5164, Bordeaux University, Bordeaux, France.
Johnny YiDepartment of Medical and Surgery Gynecology, Mayo Clinic, Phoenix, AZ, United States.
SangKon OhDepartment of Immunology, Mayo Clinic, Scottsdale, AZ, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Immunity in the vaginal mucosa (VM) is of critical importance for the protection from infections and cancers. Dendritic cells (DCs) are the major antigen-presenting cells that can induce and control T cell responses. Interestingly, VM Langerhans cells (vLCs) and VM CD1c Methods: OX40L expression was determined in the human VM tissue sections, followed by the measurement of OX40L expression on vLCs, CD1c Results: Both vLCs and CD1c Conclusions: OX40L contributes to vLC- and CD1c

Indexed as

CD4-Positive T-LymphocytesDendritic CellsMucous MembraneOX40 LigandVaginaCells, CulturedFemaleHumansLangerhans CellsLymphocyte ActivationTh2 CellsOX40 LigandTNFSF4 protein, humandendritic cellfemale genital mucosaLangerhans cellOX40LTh2vaginal mucosa

Identifiers

PMID40963615
PMCPMC12436386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.