SynthesisFrontiers in immunology2025
Efficacy and safety of camrelizumab plus apatinib for solid tumors: a meta-analysis.
Synthesis in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Efficacy and safety of camrelizumab plus apatinib in advanced urachal cancer (RUN-SC-0102): a single-arm, multicentre, phase 2 trial in China.EClinicalMedicine · 2026Article
- A conceptual blueprint for "turning cold to hot" in Osteosarcoma: from TME stratification hypotheses to adaptive therapeutic prospects.Cell communication and signaling : CCS · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study used meta-analysis to explore the efficacy and safety of camrelizumab plus apatinib in the treatment of solid tumors. Methods: PubMed, Embase, web of science, and Cochrane library databases were searched for this study, and the searches were conducted from database creation to August 13, 2025. The minors (methodological index for nonrandomized studies) score was used to evaluate the quality of the included studies, and the meta-package in R4.3.3 was used to analyze the data. Result: The analysis of 35 publications involving 2224 patients revealed various adverse events and survival outcomes. Adverse events of any grade included anemia (ES=0.446), diarrhea (ES=0.217), hypertension (ES=0.478), proteinuria (ES=0.402), and fatigue (ES=0.328). For grade1-2, adverse events, the effect sizes ranged from 0.146to 0.306. For grade ≥3 adverse events, the effect sizes ranged from 0.004 to 0.065. The Objective Response Rate (ORR) was 40.0%, with a Disease Control Rate (DCR) of 78.0%. Overall Survival (OS) rates at 6, 12, and 24 months were 79.0%, 46.5%, and 16.0%, respectively. Progression-Free Survival (PFS) rates at the same intervals were 48.4%, 19.8%, and 6.7%. Conclusion: According to the results of this meta-analysis, although the camrelizumab plus apatinib treatment regimen demonstrated certain efficacy in the short term, due to the significant limitations of this study, more high-quality, multicenter, large-sample randomized controlled studies are needed in the future to corroborate our conclusions.
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Registered trials
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