ReviewFrontiers in immunology2025
Postoperative adhesion formation: the role of peritoneal macrophages and targeting therapy.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Prior abdominal surgery characteristics predict adhesion phenotype and adhesiolysis in robotic colorectal cancer resection while preserving short-term outcomes.Surgical endoscopy · 2026Article
- Macrophage-Rich Peritoneal Compartments and CCR2-Dependent Hematopoietic Recruitment Are Differentially Associated with Adhesion Formation After Abdominal Surgery.Biomedicines · 2026Article
- Tissue-Resident Macrophage in Inflammation and Cancer.MedComm · 2026Review
- Fibrosis suppressive effect and mechanism of CaSR positive allosteric modulators/p-dioxanone copolymers.Drug delivery and translational research · 2026Article
- A Biocompatible CMCHMA/F127DA Hydrogel with ROS-Scavenging Activity Prevents Postoperative Peritoneal Adhesions.ACS omega · 2026Article
- Prevalence, patterns, and associated factors of intraperitoneal adhesions among women undergoing gynaecological laparoscopy at a private endoscopic centre in Southeastern Nigeria.Frontiers in reproductive health · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Postoperative adhesion (PA) is the most common complication of abdominal or pelvic surgery, resulting in various complications, including small bowel obstruction, secondary female infertility, chronic abdominal pain and even death. Unfortunately, there are few effective methods for the prevention and treatment of it. Previous studies confirmed that coagulation response, inflammation, fibrosis and fibrinolysis played a central role in PA formation and a variety of cells, such as monocytes, macrophages, fibroblasts, neutrophils and mesothelial cells participated in this process. Peritoneal macrophages are prominent immune cells that maintain homeostasis and coordinate cavity wound healing in serosal cavities. Aim of review: In this review, we analyze the role of peritoneal macrophages in PA formation. it also presents the latest treatment and prevention strategies targeting peritoneal macrophages. This review focuses to provide an immunological theoretical basis and new target for the prevention and treatment of PA. Key scientific concepts of review: Peritoneal macrophages recognize sterile or infected injury, initiate repair, form aggregates, and regulate coagulation, inflammation, fibrosis and fibrinolysis in PA formation. Therefore, in the most of existing strategies to prevent PA formation, the biological mechanism is related to the function of peritoneal macrophages. Targeting macrophages to prevent PA formation holds great promise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.