ArticleACS electrochemistry2025
Electrochemical Control with High Spatiotemporal Resolutions for Extracellular pH Microenvironment.
Article in ACS electrochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Operando Microscopy of Photosynthetic Microbial Biohybrids Using Fluorescent Chemical Probes.ACS electrochemistry · 2026Article
- Sculpting Microbial Microenvironments: Spatiotemporal Control via Programmable Electrochemical Gradients.Journal of the American Chemical Society · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The local pH values and hence the pH microenvironment surrounding an organism critically affect its metabolism and physiology in both prokaryotes and eukaryotes. Despite the ubiquitous spatiotemporal heterogeneity of local pH conditions in biology, a biocompatible method that spatiotemporally programs the pH microenvironment remains elusive. Here we report an electrochemical approach that spatiotemporally controls pH microenvironments for potential microbial applications. A quinone-based redox couple undergoes electrochemical proton-coupled electron transfer (PCET) that releases or consumes protons and hence changes the local pH. We designed a biocompatible hydroquinone/quinone redox couple that has minimal interference with bacterial aerobic respiration thanks to its hydrophilic nature and the specially targeted redox potential. Deploying such a uniquely designed redox couple with interdigitated electrodes in a microfluidic device leads to electrochemical control of the pH microenvironment with fast temporal modulation (~10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.