Evidence map›Paper›PMID 40963451›Full record

ArticleInternational journal of immunogenetics2025

New Evidence of TLR4 and TLR9 Variants Influencing Parasitaemia and Symptoms of Plasmodium vivax Infection.

Mikaele Monik Rodrigues Inácio Silva, Gabriela Maria Andrade Correia, Juliana Dal-Ri Lindenau, Maristela Gomes Cunha, Maria Deise Oliveira Ohnishi, Ana Maria Revoredo Silva Ventura, Ândrea Ribeiro-Dos-Santos, Mara Helena Hutz, Vinicius Albuquerque Sortica

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of immunogenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mikaele Monik Rodrigues Inácio SilvaPrograma de Pós-graduação em Ciências da Saúde, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil.
Gabriela Maria Andrade CorreiaPrograma de Pós-graduação em Ciências da Saúde, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil.
Juliana Dal-Ri LindenauDepartamento de Biologia Celular, Embriologia e Genética, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Maristela Gomes CunhaLaboratório de Microbiologia e Imunologia, Universidade Federal do Pará, Belém, Pará, Brazil.
Maria Deise Oliveira OhnishiPrograma de Ensaios Clínicos em Malária, Instituto Evandro Chagas, Sistema de Vigilância Sanitária, Ministério da Saúde, Belém, Pará, Brazil.
Ana Maria Revoredo Silva VenturaPrograma de Ensaios Clínicos em Malária, Instituto Evandro Chagas, Sistema de Vigilância Sanitária, Ministério da Saúde, Belém, Pará, Brazil.
Ândrea Ribeiro-Dos-SantosLaboratorio de Genética Humana e Médica, Programa de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Pará, Belém, Pará, Brazil.
Mara Helena HutzDepartamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Vinicius Albuquerque SorticaPrograma de Pós-graduação em Ciências da Saúde, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil.ORCID https://orcid.org/0000-0001-6185-0832

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 407025/2018-9Conselho Nacional de Desenvolvimento Científico e Tecnológico 455226/2014-8Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 104101/2020-2Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88882.316196/2019-01Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.715159/2022-00
6 · The paper itself

Abstract

Toll-like receptors (TLRs) induce the production of pro-inflammatory cytokines and regulate the immune response to Plasmodium vivax infection. Genetic variants of TLRs are associated with susceptibility and severity of malaria in different populations. This study aimed to evaluate the association between polymorphisms in TLR1, TLR4, TLR7, TLR8, TLR9 and TIRAP and the clinical manifestations of malaria caused by P. vivax in a population from the Amazon region of Pará, Brazil. A total of 148 individuals with symptomatic uncomplicated malaria were genotyped for rs4833095, rs1927911, rs179008, rs3764880, rs352140 and rs8177374 variants, and their associations with parasitaemia levels, gametocytaemia and clinical index were analysed using generalised linear models. TLR9 rs352140TT homozygotes had higher parasitaemia levels than C allele carriers (p = 0.034). TLR4 rs1927911GG homozygotes had a higher clinical index than A allele carriers (p = 0.018). Our results describe, for the first time, the association of the rs1927911 variant found in intron 1 of TLR4 with P. vivax malaria symptoms in Brazilian Amazonian population.

Indexed as

Malaria, VivaxParasitemiaPlasmodium vivaxToll-Like Receptor 4Toll-Like Receptor 9AdolescentAdultAllelesBrazilFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansMaleTLR4 protein, humanTLR9 protein, humanToll-Like Receptor 4Toll-Like Receptor 9Amazon regionBrazilgenetic variabilitymalariatoll‐like receptor

Identifiers

PMID40963451
PMCPMC12595586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.