ArticleAngewandte Chemie (International ed. in English)2025
Difluoro Carbenes: From Genuine Gold Complexes to Unprecedented Metallacyclic Reactivity.
Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Gold(III)-Substituted Carbenes.Journal of the American Chemical Society · 2026Article
- Difluoro Carbenes: From Genuine Gold Complexes to Unprecedented Metallacyclic Reactivity.Angewandte Chemie (International ed. in English) · 2025Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Difluorocarbene is a very powerful synthon in organic chemistry, but its reactivity is very challenging to tame. While a few recent studies have pinpointed the potential of transition metals such as Pd and Cu to stabilize and harness difluorocarbene, known examples are confined to relatively classical transformations. Here we report gold(I) difluorocarbenes persisting for hours at 0 °C thanks to ligand-enhanced backdonation. These complexes exhibit unforeseen reactivity with alkenes and 1,3-dienes. The key intermediates, gold(III) metallacycles, have been spectroscopically and crystallographically characterized. Choosing the ligand at gold and operating conditions (thermal or photochemical) enable to direct C─C coupling to the desired product. This novel gold-mediated two-electron redox pathway was leveraged to prepare difluorocyclopentenes, overcoming the intrinsic challenge of [1+4] cycloaddition between carbenes and 1,3-dienes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.