Evidence map›Paper›PMID 40963414›Full record

ArticlePharmacogenomics

Assessing patient understanding of pharmacogenomic test results: a qualitative study.

Tom A Doyle, Samantha L Vershaw, Karen K Schmidt, Todd C Skaar, Peter H Schwartz

Abstract read
In one paragraph

Article in Pharmacogenomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tom A DoyleIndiana University Center for Bioethics, Indiana University School of Medicine, Indianapolis, IN, USA.
Samantha L VershawIndiana University Center for Bioethics, Indiana University School of Medicine, Indianapolis, IN, USA.
Karen K SchmidtIndiana University Center for Bioethics, Indiana University School of Medicine, Indianapolis, IN, USA.
Todd C SkaarDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Peter H SchwartzIndiana University Center for Bioethics, Indiana University School of Medicine, Indianapolis, IN, USA.

Funding

Implementing genomic medicine through pragmatic trials in diverse and underserved populations across Indiana.U01HG010245 · NHGRI · INDIANA UNIVERSITY INDIANAPOLIS · PI DEXTER, PAUL, SKAAR, TODD C. · 2018 to 2024
$9.4M
NHGRI NIH HHS U01 HG010245
6 · The paper itself

Abstract

aimTo examine whether patients with depression or chronic/acute pain understand the results of pharmacogenomic testing they had done as part of clinical research.

methodsSemi-structured interviews were conducted with 45 patients who underwent pharmacogenomic testing and subsequently received their testing results by mail. These interviews assessed whether participants were aware that they had testing, how this testing impacted their current medications, and whether they grasped the future significance of this testing. A grounded theory approach was used to analyze this interview data.

resultsAll of our participants were aware that they had underwent medical testing and 23 (51%) were aware that this testing was genetic and was used to guide medication management. Almost all of our participants believed it was important to share their results with future providers and 24 (53%) recognized that their results could impact future medication management. Thirteen (29%) participants stated that their results found medicines they should avoid and eight named specific medicines they believed should be avoided based on their results.

conclusionAlthough our participants exhibited a general understanding of their pharmacogenomic results, we found that they lacked a sufficient understanding of how these results specifically impacted their current and future healthcare.

Indexed as

ComprehensionHealth Knowledge, Attitudes, PracticePharmacogeneticsPharmacogenomic TestingAdultAgedDepressionFemaleHumansMaleMiddle AgedQualitative Researchpain pharmacologyPatient educationpatient understandingpharmacogenomic counselingpsychiatric pharmacology

Identifiers

PMID40963414
PMCPMC12582057

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.