Observational studyCancer control : journal of the Moffitt Cancer Center
Prognostic Value of Handgrip Strength in Lung Cancer: Findings From a Multicenter Prospective Cohort Study.
Observational study in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BackgroundHandgrip strength (HGS), a simple and practical indicator of skeletal muscle function, has emerged as a potential prognostic marker, yet its predictive value in lung cancer remains to be fully elucidated. This study aimed to evaluate the prognostic significance of HGS for Overall Survival (OS) in patients with lung cancer, and to develop a prognostic model integrating HGS and hematologic parameters.MethodsThis prospective cohort study was based on the Investigation on Nutrition Status and its Clinical Outcome of Common Cancers (INSCOC). A total of 3604 pathologically confirmed lung cancer patients were included. Demographic, clinical, and nutrition-related data were collected. The association between HGS and OS was assessed using Cox proportional hazards models. A nomogram was developed, and its predictive performance was evaluated using receiver operating characteristic (ROC) curves and the concordance index (C-index).ResultsHGS was significantly associated with OS in patients with lung cancer. Compared with the lowest quartile (Q1), patients in Q2, Q3, and Q4 showed 23.9% (HR = 0.761, 95% CI: 0.666-0.869,
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