Evidence map›Paper›PMID 40963302›Full record

ArticleAnnals of clinical and translational neurology2025

A Multi-Center Retrospective Cohort Study of Neurosarcoidosis Myelitis: Current Observations and Future Directions.

Giovanna S Manzano, Denis Balaban, Yihan Zhang, Brian Healy, Bart K Chwalisz, Michael Levy, Nagagopal Venna, Barney J Stern, Carlos A Pardo, Paula Barreras and 30 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors.

Giovanna S ManzanoDepartment of Neurology, Mass General Brigham, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-9991-9222
Denis BalabanDepartment of Neurology, Mass General Brigham, Harvard Medical School, Boston, Massachusetts, USA.
Yihan ZhangDepartment of Neurology, Mass General Brigham, Harvard Medical School, Boston, Massachusetts, USA.
Brian HealyDepartment of Neurology, Mass General Brigham, Harvard Medical School, Boston, Massachusetts, USA.
Bart K ChwaliszDepartment of Neurology, Mass General Brigham, Harvard Medical School, Boston, Massachusetts, USA.
Michael LevyDepartment of Neurology, Mass General Brigham, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-7969-8346
Nagagopal VennaDepartment of Neurology, Mass General Brigham, Harvard Medical School, Boston, Massachusetts, USA.
Barney J SternDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Carlos A PardoDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-4128-5335
Paula BarrerasDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nicole Bou RjeilyDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Eoin P FlanaganDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Vyanka RedenbaughDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Allen J AksamitDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Spencer HuttoDepartment of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.
Max HermanDepartment of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.
Sally El SammakDepartment of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.
Elsa C RodriguezDepartment of Neurology, University of Florida, College of Medicine, Gainesville, Florida, USA.
Laura SniderDepartment of Neurology, University of Florida, College of Medicine, Gainesville, Florida, USA.
Hannah RainsDepartment of Neurology, University of Florida, College of Medicine, Gainesville, Florida, USA.
Mayra MontalvoDepartment of Neurology, University of Florida, College of Medicine, Gainesville, Florida, USA.
Torge RempeDepartment of Neurology, University of Florida, College of Medicine, Gainesville, Florida, USA.
Sergi Martinez RamirezDepartment of Neurology, Mass General Brigham, Harvard Medical School, Boston, Massachusetts, USA.
Lucas HortaDepartment of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.
Stacey ClardyDepartment of Neurology, University of Utah Health, Salt Lake City, Utah, USA.
Jennifer LordDepartment of Neurology, University of Utah Health, Salt Lake City, Utah, USA.
Tracey A ChoDepartment of Neurology, University of Iowa Health Care, Iowa City, Iowa, USA.
Lama Abdel WahedDepartment of Neurology, University of Iowa Health Care, Iowa City, Iowa, USA.
Joseph R BergerDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-1540-496X
Rohini D SamudralwarDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-1224-4996
Noellie Rivera TorresDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
David B CliffordDepartment of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.
Steven Richard DunhamDepartment of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0003-2840-3955
Masoud MajedDepartment of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.
Aram ZabetiDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Samuel MarcucciDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Yang Mao-DraayerAutoimmunity Center of Excellence, Oklahoma Medical Research Foundation, Oklahoma, Oklahoma City, USA.
Jon DotyMichigan Institute for Neurological Disorders, Farmington Hills, Michigan, USA.
Paunel B AgyeiDepartment of Neurology, UTHealth Houston, Houston, Texas, USA.
Shamik BhattacharyyaDepartment of Neurology, Mass General Brigham, Harvard Medical School, Boston, Massachusetts, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe optimal treatment for neurosarcoidosis myelitis is uncertain. We characterize incident neurosarcoidosis myelitis and assess treatment response by MRI and clinical scales.

methodsIncident probable or definite neurosarcoidosis myelitis in adults was retrospectively identified from 13 academic medical centers. Cases were analyzed by initial treatment. The primary outcome was T1 post-contrast gadolinium enhancement resolution at 6 months post-treatment. Secondary outcomes were changes in modified Rankin scale (mRS) and Expanded Disability Status Scale (EDSS) from nadir to final follow-up.

resultsTwo hundred two patients were identified (median diagnosis age: 47 years (IQR 39-55); male: female 1.3:1). Median nadir mRS and EDSS were 2 (IQR 2-3) and 4 (IQR 2.5-6). At initial treatment, 129 (63.9%) received prolonged corticosteroids ≥ 4 weeks (group A

interpretationDifferent initial immunosuppression strategies did not correlate with MRI contrast enhancement resolution at 6 months or clinical scales (mRS, EDSS). However, conclusions are limited by retrospective design, imbalanced cohorts, and insensitivity of binary MRI outcomes and available clinical scales for treatment response in neurosarcoidosis.

Indexed as

Adrenal Cortex HormonesCentral Nervous System DiseasesImmunosuppressive AgentsMyelitisSarcoidosisAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesAdrenal Cortex HormonesImmunosuppressive Agentsmyelitisneuroimmunologyneurosarcoidosis

Identifiers

PMID40963302
PMCPMC12698951

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