Evidence map›Paper›PMID 40963202›Full record

Trial reportJournal of the International Society of Sports Nutrition2025

Single high-dose vitamin D supplementation impacts ultramarathon-induced changes in serum levels of bone turnover markers: a double-blind randomized controlled trial.

Błażej Stankiewicz, Andrzej Kochanowicz, Paulina Brzezińska, Bartłomiej Niespodziński, Joanna Reczkowicz, Tomasz Waldziński, Tomasz Kowalik, Elżbieta Piskorska, Ewelina Wędrowska, Jędrzej Antosiewicz and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03417700 (Vitamin D as a Factor Modifying Adaptation to Diverse Forms of Exercise), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03417700 nacompletednot on this map

Vitamin D as a Factor Modifying Adaptation to Diverse Forms of Exercise

TypeinterventionalSponsorGdansk University of Physical Education and SportRan2018 to 2020Enrolled100ConditionsVitamin D3 DeficiencyArmsNW training, Placebo, HICT
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Błażej StankiewiczDepartment of Theory and Methodology of Physical Education and Sport, The Faculty of Health Sciences and Physical Education, Bydgoszcz, Poland.ORCID 0000-0001-6743-1073
Andrzej KochanowiczDepartment of Gymnastics and Dance, Gdańsk University of Physical Education and Sport, Gdańsk, Poland.
Paulina BrzezińskaDepartment of Gymnastics and Dance, Gdańsk University of Physical Education and Sport, Gdańsk, Poland.ORCID 0000-0001-5274-6208
Bartłomiej NiespodzińskiDepartment of Biological Foundations of Physical Education, The Faculty of Health Sciences and Physical Education, Kazimierz Wielki University, Bydgoszcz, Poland.ORCID 0000-0001-8992-3730
Joanna ReczkowiczDepartment of Bioenergetics and Physiology of Exercise, Medical University of GdańskPoland.ORCID 0000-0002-9944-1687
Tomasz WaldzińskiFaculty of Health Sciences, University of Lomza, Łomża, Poland.ORCID 0000-0003-3181-6283
Tomasz KowalikDepartment of Theory and Methodology of Physical Education and Sport, The Faculty of Health Sciences and Physical Education, Bydgoszcz, Poland.ORCID 0000-0001-9971-932X
Elżbieta PiskorskaDepartment of Pathobiochemistry and Clinical Chemistry, Nicolaus Copernicus University Collegium Medicum, Bydgoszcz, Poland.ORCID 0000-0003-4622-4993
Ewelina WędrowskaDepartment of Lung Diseases, Neoplasms and Tuberculosis, L. Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Bydgoszcz, Poland.ORCID 0000-0003-4478-6749
Jędrzej AntosiewiczDepartment of Bioenergetics and Physiology of Exercise, Medical University of GdańskPoland.ORCID 0000-0002-7871-6469
Jan MieszkowskiDepartment of Gymnastics and Dance, Gdańsk University of Physical Education and Sport, Gdańsk, Poland.ORCID 0000-0001-6753-5139

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent studies indicate a protective role of vitamin D supplementation against sports performance-induced dysregulation of body homeostasis. However, the effects of a single high dose of vitamin D on changes in bone formation and resorption markers due to ultramarathon running have yet to be explored. This study aimed to analyze the effect of a single high-dose vitamin D supplementation on serum levels of bone turnover markers after a mountain ultramarathon run.

methodsIn this clinical trial (reg. number NCT03417700), 35 semiprofessional male ultramarathon runners were assigned into two groups: supplemented group, administered a single high dose of vitamin D

resultsSerum 25(OH)D

conclusionsThe observed attenuation of post-exercise bone resorption and enhancement of bone formation suggest that vitamin D supplementation may modulate bone metabolism in response to extreme physical exertion, potentially through effects on calcium - PTH homeostasis.

Indexed as

Bone RemodelingCholecalciferolDietary SupplementsMarathon RunningRunningAdultBiomarkersCalcifediolCollagen Type IDouble-Blind MethodHumansMaleMiddle AgedParathyroid HormonePeptide FragmentsPeptidesBiomarkersCalcifediolCholecalciferolCollagen Type Icollagen type I trimeric cross-linked peptideParathyroid HormonePeptide FragmentsPeptidesProcollagenprocollagen Type I N-terminal peptideVitamin DCTXPINPsclerostinskeletal muscle damageUltramarathonvitamin D

Identifiers

PMID40963202
PMCPMC12447467

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.