ArticleWorld journal of surgical oncology2025
Sarcopenia and fat loss from serial CT predict survival in multiple myeloma patients undergoing stem cell transplantation.
Article in World journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- AI-derived whole-body MRI metrics in patients with multiple myeloma reveal unique insights into body composition and outcomes.Blood advances · 2026Observational
- Postoperative loss of skeletal muscle mass and visceral fat predicts survival and morbidity after surgically treated non-metastatic chondrosarcoma: a longitudinal CT morphometric study.World journal of surgical oncology · 2026Article
- Advances in the application of frailty scoring in the diagnosis and management of elderly patients with multiple myeloma (Review).Oncology reports · 2026Review
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7 authors.
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Abstract
backgroundFrailty and sarcopenia are associated with adverse outcomes in multiple myeloma (MM), but their longitudinal changes and clinical relevance remain unclear. This study evaluated the longitudinal changes in body composition parameters derived from computed tomography (CT) scans and their association with survival and functional decline in MM patients undergoing autologous stem cell transplantation (ASCT).
methodsWe analyzed 49 MM patients who underwent three sequential CT scans between 2009 and 2024. CT-based body composition parameters-skeletal muscle index (SMI), paraspinal muscle index (PSMI), psoas muscle index (PMI), skeletal muscle density (SMD), and visceral adipose tissue (VAT)-were measured at the L3 level. Changes in these parameters were assessed over the disease course, and their impact on survival and functional outcome was evaluated using Cox proportional hazards regression models and Kaplan-Meier survival analyses.
resultsCT morphometric body composition parameters declined significantly over time in both sexes. In males, SMI decreased from 48.6 ± 7.1 to 38.4 ± 8.1 cm
conclusionLongitudinal changes in SMI and VAT were significant predictors of survival and functional decline in MM patients undergoing ASCT. Routine CT-based body composition assessments might serve as valuable tools for additional risk stratification and potential targeted interventions. These findings underscore the importance of integrating body composition analysis into clinical practice for improved risk stratification and potential implementation of early intervention strategies.
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