ArticleApoptosis : an international journal on programmed cell death2025
His-tagged pro-apoptotic peptides: enhancing cell internalization and anticancer effect in vitro.
Article in Apoptosis : an international journal on programmed cell death, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Epidermal growth factor receptor (EGFR) overexpression is commonly found in various solid tumors, including non-small cell lung cancer, where it is associated with poor prognosis and resistance to treatment. Despite the availability of EGFR-targeted therapies, overcoming drug resistance remains a challenge. Tumor-homing cell-penetrating peptides can selectively target cancer cells and improve drug delivery. In this study, we evaluated the anticancer potential of EGFR-targeted pro-apoptotic peptides, specifically NRPD-KLAK-H and NRPD-CTMP4-H, designed to enhance internalization and overcome drug resistance in EGFR-positive cancers, and compared their effects with those of the free His-tagged peptides NRPD-H, KLAK-H, and CTMP4-H. MTT assays showed that KLAK-H and NRPD-KLAK-H exhibited the strongest anticancer effects, significantly inhibiting cell growth in A-549 cell line, with IC
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