Evidence map›Paper›PMID 40963019›Full record

ArticleNature2025

Learning the natural history of human disease with generative transformers.

Artem Shmatko, Alexander Wolfgang Jung, Kumar Gaurav, Søren Brunak, Laust Hvas Mortensen, Ewan Birney, Tom Fitzgerald, Moritz Gerstung

Erratum issuedAbstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 62 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Artificial intelligence virtual bone organoids (AIVBOs).Journal of orthopaedic translation · 2026
    Review
  10. MAFLD/MASLD: Past, Present, and Future.Journal of gastroenterology and hepatology · 2026
    Review
  11. Article
  12. Article
  13. Observational
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Artem Shmatko *Division of AI in Oncology, German Cancer Research Centre DKFZ, Heidelberg, Germany.ORCID 0000-0002-2184-0856
Alexander Wolfgang Jung *European Molecular Biology Laboratory, European Bioinformatics Institute EMBL-EBI, Hinxton, UK.ORCID 0000-0001-8416-6849
Kumar Gaurav *European Molecular Biology Laboratory, European Bioinformatics Institute EMBL-EBI, Hinxton, UK.
Søren BrunakNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-0316-5866
Laust Hvas MortensenStatistics Denmark, Copenhagen, Denmark.
Ewan BirneyEuropean Molecular Biology Laboratory, European Bioinformatics Institute EMBL-EBI, Hinxton, UK. birney@ebi.ac.uk.ORCID 0000-0001-8314-8497
Tom FitzgeraldEuropean Molecular Biology Laboratory, European Bioinformatics Institute EMBL-EBI, Hinxton, UK. tomas@ebi.ac.uk.ORCID 0000-0002-2370-8496
Moritz GerstungDivision of AI in Oncology, German Cancer Research Centre DKFZ, Heidelberg, Germany. moritz.gerstung@dkfz.de.ORCID 0000-0001-6709-963X

Funding

Deutsches Krebsforschungszentrum
6 · The paper itself

Abstract

Decision-making in healthcare relies on understanding patients' past and current health states to predict and, ultimately, change their future course

Indexed as

Artificial IntelligenceDiseaseDisease ProgressionBiological Specimen BanksComorbidityDenmarkFemaleHumansMale

Identifiers

PMID40963019
PMCPMC12589094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.