Evidence map›Paper›PMID 40963018›Full record

ArticleNature2025

Selective presynaptic inhibition of leg proprioception in behaving Drosophila.

Chris J Dallmann, Yichen Luo, Sweta Agrawal, Akira Mamiya, Grant M Chou, Andrew Cook, Anne Sustar, Bingni W Brunton, John C Tuthill

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
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  11. Comparative connectomics of the descending and ascending neurons of thebioRxiv : the preprint server for biology · 2024
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Chris J DallmannDepartment of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA.
Yichen LuoDepartment of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA.ORCID 0000-0002-2265-1117
Sweta AgrawalDepartment of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA.
Akira MamiyaDepartment of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA.ORCID 0000-0002-3199-5341
Grant M ChouDepartment of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA.
Andrew CookDepartment of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA.
Anne SustarDepartment of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA.
Bingni W BruntonDepartment of Biology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-4831-3466
John C TuthillDepartment of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA. tuthill@uw.edu.ORCID 0000-0002-5689-5806

Funding

Project 4: Neural Basis of Behavioral SequencesU19NS104655 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI WILSON, RACHEL · 2017 to 2021
$14.6M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Cale Whitworth · 2014 to 2026
$13.5M
Tools to broaden access to high-throughput functional connectomicsRF1MH117808 · NIMH · HARVARD MEDICAL SCHOOL · PI LEE, WEI-CHUNG ALLEN, MACRINA, THOMAS · 2019 to 2019
$4.3M
Neural coding of leg proprioceptionR01NS102333 · NINDS · UNIVERSITY OF WASHINGTON · PI John Tuthill · 2017 to 2026
$3.6M
Dissecting circuit and cellular mechanisms for limb motor controlRF1NS128785 · NINDS · UNIVERSITY OF WASHINGTON · PI TUTHILL, JOHN · 2022 to 2022
$1.1M
Dissecting circuit and cellular mechanisms for limb motor controlR01NS128785 · NINDS · UNIVERSITY OF WASHINGTON · PI John Tuthill · 2025 to 2026
$643k
Context-dependent neural processing of leg proprioception in DrosophilaK99NS117657 · NINDS · UNIVERSITY OF WASHINGTON · PI AGRAWAL, SWETA · 2020 to 2021
$203k
NIH HHS P40 OD018537NIMH NIH HHS RF1 MH117808NINDS NIH HHS K99 NS117657NINDS NIH HHS R01 NS102333NINDS NIH HHS R01 NS128785NINDS NIH HHS RF1 NS128785NINDS NIH HHS U19 NS104655
6 · The paper itself

Abstract

Controlling arms and legs requires feedback from the proprioceptive sensory neurons that detect joint position and movement

Indexed as

Drosophila melanogasterNeural InhibitionPresynaptic TerminalsProprioceptionAnimalsAxonsCalciumConnectomeExtremitiesFemaleGroomingInterneuronsMaleMovementSensory Receptor CellsWalkingCalcium

Identifiers

PMID40963018
PMCPMC13070307

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.