Evidence map›Paper›PMID 40963017›Full record

ArticleNature2025

Myeloperoxidase transforms chromatin into neutrophil extracellular traps.

Garth Lawrence Burn, Tobias Raisch, Sebastian Tacke, Moritz Winkler, Daniel Prumbaum, Stephanie Thee, Niclas Gimber, Stefan Raunser, Arturo Zychlinsky

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. ActivatableChemical science · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Phagosome maturation during fungal infection.Current opinion in microbiology · 2026
    Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Garth Lawrence Burn *Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany.
Tobias Raisch *Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany.ORCID 0000-0002-6531-3812
Sebastian TackeDepartment of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany.
Moritz WinklerDepartment of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany.ORCID 0009-0006-1584-2536
Daniel PrumbaumDepartment of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany.ORCID 0000-0001-7448-9951
Stephanie TheeDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Niclas GimberAdvanced Medical Bioimaging Core Facility, Charité-Universitätsmedizin, Berlin, Germany.ORCID 0000-0001-9456-3063
Stefan RaunserDepartment of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany. stefan.raunser@mpi-dortmund.mpg.de.ORCID 0000-0001-9373-3016
Arturo ZychlinskyDepartment of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany. zychlinsky@mpiib-berlin.mpg.de.ORCID 0000-0001-6018-193X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutrophils, the most abundant and biotoxic immune cells, extrude nuclear DNA into the extracellular space to maintain homeostasis. Termed neutrophil extracellular traps (NETs), these protein-modified and decondensed extracellular DNA scaffolds control infection and are involved in coagulation, autoimmunity and cancer

Indexed as

ChromatinExtracellular TrapsNeutrophilsPeroxidaseDNAHumansModels, MolecularNucleosomesProtein BindingProtein MultimerizationChromatinDNAMPO protein, humanNucleosomesPeroxidase

Identifiers

PMID40963017
PMCPMC12629992

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.