Evidence map›Paper›PMID 40963015›Full record

ArticleNature2025

Peroxisomal metabolism of branched fatty acids regulates energy homeostasis.

Xuejing Liu, Anyuan He, Dongliang Lu, Donghua Hu, Min Tan, Abenezer Abere, Parniyan Goodarzi, Bilal Ahmad, Brian Kleiboeker, Brian N Finck and 11 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Advances in research on thermogenic substances.Journal of physiological anthropology · 2026
    Review
  12. CabioRxiv : the preprint server for biology · 2026
    Article
  13. A Thermo-Sensitive Molecular Switch:International journal of molecular sciences · 2026
    Article
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Xuejing LiuDivision of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Anyuan HeDivision of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Dongliang LuDivision of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Donghua HuDivision of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Min TanDivision of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Abenezer AbereDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO, USA.
Parniyan GoodarziDivision of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Bilal AhmadDivision of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-5848-4349
Brian KleiboekerDivision of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-3196-1803
Brian N FinckDivision of Geriatrics and Nutritional Science, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-5411-3674
Mohamed ZayedDepartment of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-6443-4527
Katsuhiko FunaiDiabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT, USA.
Jonathan R BrestoffDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-7018-7400
Ali JavaheriCardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Patricia WeisenseeDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0003-0283-9347
Bettina MittendorferDepartment of Medicine, University of Missouri School of Medicine, Columbia, MO, USA.
Fong-Fu HsuDivision of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Paul P Van VeldhovenLaboratory of Peroxisome Biology and Intracellular Communication, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
Babak RazaniUniversity of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA.ORCID 0000-0002-7172-9240
Clay F SemenkovichDivision of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-1163-1871
Irfan J LodhiDivision of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. ilodhi@wustl.edu.ORCID 0000-0002-6246-9862

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Jennifer Lynn Powers Carson · 2013 to 2026
$27.1M
TRANSGENICS COREP60DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI SCHAFFER, JEAN E. · 1986 to 2012
$25.2M
DIABETES &RELATED METABOLIC DISEASEST32DK007120 · NIDDK · WASHINGTON UNIVERSITY · PI MARCO COLONNA, Maria Sara Remedi · 1986 to 2026
$15.7M
TrainingP41GM103422 · NIGMS · WASHINGTON UNIVERSITY · PI YARASHESKI, KEVIN E · 2012 to 2019
$12.0M
BCFA Metabolism and the Regulation of Energy BalanceR01DK133344 · NIDDK · WASHINGTON UNIVERSITY · PI Irfan J Lodhi, Clay F. Semenkovich · 2023 to 2026
$2.0M
Mitochondrial dynamics and the control of adipose tissue thermogenesisR01DK132239 · NIDDK · WASHINGTON UNIVERSITY · PI Irfan J Lodhi · 2022 to 2026
$1.9M
REGULATION OF ADIPOSE TISSUE REMODELING AND ENERGY HOMEOSTASISR01DK115867 · NIDDK · WASHINGTON UNIVERSITY · PI LODHI, IRFAN J · 2018 to 2022
$1.9M
Phenomaster NG Mouse Metabolic Phenotyping SystemS10OD032315 · OD · WASHINGTON UNIVERSITY · PI FINCK, BRIAN N · 2022 to 2022
$524k
NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK056341NIDDK NIH HHS P60 DK020579NIDDK NIH HHS R01 DK115867NIDDK NIH HHS R01 DK132239NIDDK NIH HHS R01 DK133344NIDDK NIH HHS T32 DK007120NIGMS NIH HHS P41 GM103422NIH HHS S10 OD032315
6 · The paper itself

Abstract

Brown and beige adipocytes express uncoupling protein 1 (UCP1), a mitochondrial protein that dissociates respiration from ATP synthesis and promotes heat production and energy expenditure. However, UCP1

Indexed as

Energy MetabolismFatty AcidsHomeostasisPeroxisomesAcyl-CoA OxidaseAdenosine TriphosphateAdipose Tissue, BrownAnimalsCold TemperatureFatty Acid SynthasesFemaleInsulin ResistanceMaleMiceObesityOxidation-ReductionAcyl-CoA OxidaseAdenosine TriphosphateFatty AcidsFatty Acid SynthasesUncoupling Protein 1

Identifiers

PMID40963015
PMCPMC12571886

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.