Evidence map›Paper›PMID 40962961›Full record

ArticleAnnals of surgical oncology2026

Clinicopathological Features and Management of Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS).

Shruthi R Perati, Amber F Gallanis, Disha Sharma, Gracia Viana Rodriguez, Grace-Ann Fasaye, Rachael Lopez, Cassidy Bowden, Sun A Kim, Andrew M Blakely, Jonathan M Hernandez and 3 more

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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shruthi R PeratiSurgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Amber F GallanisSurgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Disha SharmaDigestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Gracia Viana RodriguezDigestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Grace-Ann FasayeGenetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Rachael LopezClinical Center Nutrition Department, National Institutes of Health, Bethesda, MD, USA.
Cassidy BowdenSurgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Sun A KimLaboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Andrew M BlakelySurgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Jonathan M HernandezSurgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Louis KormanDigestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Theo HellerTranslational Hepatology Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Liver Diseases Branch, Bethesda, MD, USA.
Jeremy L DavisDivision of Surgical Oncology, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA. Jeremy.Davis@som.umaryland.edu.ORCID http://orcid.org/0000-0002-6334-6936

Funding

Surgical Oncology Program Training ProgramZIEBC012097 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BLAKELY, ANDREW · 2022 to 2025
$17.3M
Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIE BC012097National Institutes of Health, National Cancer Institute (NCI) The Intramural Research Program of the National In
6 · The paper itself

Abstract

backgroundGastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) is a rare hereditary gastric cancer syndrome linked to APC promoter IB variants and characterized by gastric polyposis. Its natural history and management are poorly defined. We sought to characterize the clinicopathological features of GAPPS and infer management guidelines. PATIENTS AND

methodsWe retrospectively analyzed individuals with GAPPS enrolled in a natural history study from January 2017 to September 2023. Demographics, pathogenic gene variants, endoscopic findings, and histopathology results were studied.

resultsOf 21 patients with GAPPS, 11 (52%) were male, and most were non-Hispanic white (71%). Median age at germline genetic testing was 44 years (range 12-75 years), and all individuals had a pathogenic variant in the APC promoter IB. Esophagogastroduodenoscopy (EGD) was performed in almost all patients (91%), with a median age of 37 years (range 12-75 years) at initial EGD. Gastric polyps carpeting the fundus and body with antral sparing were noted in all individuals. Gastric adenocarcinoma (n = 3), high-grade dysplasia (n = 7), low-grade dysplasia (n = 3), and benign fundic gland polyposis (n = 6) were demonstrated on endoscopic biopsies. Then, 43% (9/21) of patients underwent total gastrectomy (TG) at a median age of 44 years (range 15-63 years). Histopathology of final gastrectomy specimens demonstrated more advanced pathology compared with endoscopic biopsies in five of nine patients.

conclusionsGiven the challenge of effective endoscopic surveillance owing to extensive polyposis, and the risk of malignant transformation, prophylactic TG should be considered for patients with GAPPS. Longitudinal studies are needed to delineate lifetime cancer risk and clinical management guidelines.

Indexed as

AdenocarcinomaAdenomatous PolypsStomach NeoplasmsAdolescentAdultAgedChildFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesYoung Adult

Identifiers

PMID40962961
PMCPMC13591488

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.