Evidence map›Paper›PMID 40962953›Full record

ArticleCellular & molecular immunology2025

Infiltrating macrophages replace Kupffer cells and play diverse roles in severe alcohol-associated hepatitis.

Yang Wang, Yukun Guan, Dechun Feng, Luca Maccioni, Maria A Parra, Brandon Peiffer, Bryan Mackowiak, Takashige Kuwabara, Kiyoshi Mori, Masashi Mukoyama and 3 more

Abstract read
In one paragraph

Article in Cellular & molecular immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Kupffer cells: Orchestrators of liver physiology.Liver research (Beijing, China) · 2026
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. International journal of nanomedicine · 2026
    Article
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yang Wang *Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA.
Yukun Guan *Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA.ORCID 0000-0001-9312-0164
Dechun FengLaboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA.ORCID 0000-0001-7485-762X
Luca MaccioniLaboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA.
Maria A ParraDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Brandon PeifferDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Bryan MackowiakLaboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA.
Takashige KuwabaraDepartment of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.
Kiyoshi MoriDepartment of Nephrology and Kidney Research, Shizuoka General Hospital, Shizuoka, Japan.
Masashi MukoyamaDepartment of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.
Ramon BatallerLiver Unit, Hospital Clinic, Barcelona, Spain.
Zhaoli SunDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Bin GaoLaboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA. bgao@mail.nih.gov.ORCID 0000-0002-0505-2972

Funding

Clinical Resources for Alcoholic Hepatitis InvestigationsR24AA025017 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI ZHAOLI SUN · 2016 to 2026
$6.6M
NIAAA NIH HHS R24 AA025017U.S. Department of Health & Human Services | National Institutes of Health (NIH) Intramural program
6 · The paper itself

Abstract

Patients with alcohol-associated cirrhosis (AC) may develop severe alcohol-associated hepatitis (sAH), a disease with high short-term mortality. Our previous studies demonstrated that sAH, but not AC livers, are infiltrated with a high number of self-sustaining IL-8

Indexed as

Hepatitis, AlcoholicKupffer CellsMacrophagesAnimalsApolipoproteins ECalgranulin AComplement C1qHumansLiverLiver Cirrhosis, AlcoholicMaleMiceMice, Inbred C57BLMice, KnockoutNeutrophilsPhagocytosisApolipoproteins ECalgranulin AComplement C1qAPOEC1QMacrophagesNeutrophil apoptosisS100A8

Identifiers

PMID40962953
PMCPMC12480828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.