ReviewNature reviews. Chemistry2025
The impact of supramolecular self-association of organocatalysts on catalytic performance.
Review in Nature reviews. Chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Role of 2-Hydroxyimines in Chiral Phosphoric Acid-Catalyzed Mannich-Type Reactions: Enhancing Reactivity and Selectivity via Dimerization.Journal of the American Chemical Society · 2026Article
- Intermolecular Stacking-Instructed Chiral Preference in Covalent 2 + 2 Macrocyclization.JACS Au · 2026Article
- Chirality Evolution in Supramolecular Polymers: Homochiral Aggregation and Temperature-Dependent Chirality Reversal.ACS polymers Au · 2026Article
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Authors and funding
3 authors.
Funding
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Abstract
Organocatalysis has emerged as a powerful tool in homogeneous catalysis, and especially in enantioselective catalysis. Importantly, the functional groups that are key to the reactivity of organocatalysts also allow for noncovalent interactions between catalyst molecules, both in the absence and in the presence of the reaction substrates. Such noncovalent interactions can lead to catalyst self-association, which can affect the catalytic behaviour of the respective organocatalyst, in terms of both reaction rates and enantioselectivities. In this Review, we present examples of such catalyst self-association in various organocatalysts, including ureas, thioureas, squaramides, peptides, silanediols and phosphoric acids. We analyse the known solid-state and solution-phase structures and discuss the influence of self-association in catalysis. We hope to illustrate the importance of catalyst self-association, which should be taken into account by practitioners of organocatalysis and catalyst designers.
Identifiers
40962948What OpenQuestion holds
Registered trials
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