Evidence map›Paper›PMID 40962941›Full record

ArticleEMBO molecular medicine2025

Glycans on non-structural protein 1 prevent premature T-cell mediated dengue virus clearance.

Fakhriedzwan Idris, Justin Seng Geap Ooi, Donald Heng Rong Ting, Eunice Tze Xin Tan, Corrine Wan, Peter I Benke, Jan K Marzinek, Jack M Copping, Qin Hui Li, Lu Yi Ng and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Fakhriedzwan IdrisInfectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117545, Singapore.ORCID http://orcid.org/0000-0003-2128-4279
Justin Seng Geap OoiEmerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore, 169857, Singapore.ORCID http://orcid.org/0000-0003-4899-8255
Donald Heng Rong TingInfectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117545, Singapore.ORCID http://orcid.org/0000-0001-8994-2747
Eunice Tze Xin TanInfectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117545, Singapore.
Corrine WanBioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), Singapore, 138668, Singapore.ORCID http://orcid.org/0000-0002-5232-9313
Peter I BenkePrecision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117596, Singapore.ORCID http://orcid.org/0009-0008-0380-6831
Jan K MarzinekBioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, 138671, Singapore.ORCID http://orcid.org/0000-0002-5493-8753
Jack M CoppingBiomolecular Interaction Centre, Digital Life Institute, Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag, Auckland, 92019, New Zealand.
Qin Hui LiInfectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117545, Singapore.ORCID http://orcid.org/0000-0002-2792-9018
Lu Yi NgImmunology Programme, Life Sciences Institute, National University of Singapore, Singapore, 117456, Singapore.ORCID http://orcid.org/0009-0001-0577-2347
Sheau Yng LimImmunology Programme, Life Sciences Institute, National University of Singapore, Singapore, 117456, Singapore.
Ian WalshBioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), Singapore, 138668, Singapore.
Jane R AllisonBiomolecular Interaction Centre, Digital Life Institute, Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag, Auckland, 92019, New Zealand.
Peter J BondBioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, 138671, Singapore.ORCID http://orcid.org/0000-0003-2900-098X
Federico TortaPrecision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117596, Singapore.
Terry Nguyen-KhuongBioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), Singapore, 138668, Singapore.
Kuan Rong ChanEmerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore, 169857, Singapore.
Sylvie AlonsoInfectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117545, Singapore. micas@nus.edu.sg.ORCID http://orcid.org/0000-0001-7044-414X

Funding

MOH | National Medical Research Council (NMRC) MOH-000087PMO | National Research Foundation Singapore (NRF) NRF-CRP27-2021-0003
6 · The paper itself

Abstract

Non-structural protein 1 (NS1) of dengue virus (DENV) harbours two conserved N-glycosylation sites at positions 130 and 207, whose biological roles have remained elusive. Using a clinically relevant mouse model of severe dengue, we showed that DENV that lacked N207 glycans on NS1 was significantly attenuated, and this phenotype was dominant over wild-type virulent DENV. Mice infected with this mutant exhibited accelerated viral clearance, milder lymphopenia and more functional DENV-specific CD8

Indexed as

CD8-Positive T-LymphocytesDengueDengue VirusPolysaccharidesT-LymphocytesViral Nonstructural ProteinsAnimalsApoptosisB7-H1 AntigenDisease Models, AnimalGlycosylationHumansImmunity, InnateMiceMice, Inbred C57BLProgrammed Cell Death 1 ReceptorB7-H1 AntigenPolysaccharidesProgrammed Cell Death 1 ReceptorViral Nonstructural ProteinsDengueGlycosylationNS1PD-1T-cell Apoptosis

Identifiers

PMID40962941
PMCPMC12603335

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.