ArticleNature medicine2025
An implantable system to restore hemodynamic stability after spinal cord injury.
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Article in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14citing papers in PubMed, 1 pooled it
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Spinal cord stimulation to manage autonomic dysfunction after spinal cord injury: a systematic review.Frontiers in human neuroscience · 2026Pooled it
- In conversation with Grégoire Courtine.Nature neuroscience · 2026Article
- Exercise and Autonomic Cardiovascular Function-Insights From Spinal Cord-Injured Humans: A Narrative Review.Acta physiologica (Oxford, England) · 2026Review
- Association between blood pressure instability and health-related quality of life in people with spinal cord injury.Spinal cord · 2026Article
- Surface circumferential spinal cord recording in freely moving rodents.Nature communications · 2026Article
- Spinal cord neuromodulation for autonomic recovery following spinal cord injury: a scoping review.Journal of neuroengineering and rehabilitation · 2026Article
- Validating the ADFSCI hypotension symptom domain as a scalable patient reported outcome measure in spinal cord injury.NPJ digital medicine · 2026Article
- Asymmetric tripolar nerve cuff electrode designs for optimizing anodal block of myelinated fibers.Biomedical engineering online · 2026Article
- Electroceuticals for Paralympic Athletes: A Fair Play and Classification Concern?Sports medicine (Auckland, N.Z.) · 2026Review
- Graph-Theoretical Signature from Neural and Vascular Signals Reveals Spinal Cord Stimulation Frequency-Specific Brain Network in Disorders of Consciousness Patients.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- Safety of transcutaneous electrical stimulation potentiating recovery in acute spinal cord injury syndromes: a trial protocol.Frontiers in neuroscience · 2026Article
- Advances in Bionic Therapies for Targeting Neural Circuit Reconstruction and Integration for Spinal Cord Injury.Cellular and molecular neurobiology · 2025Review
- Article
- An implantable system to restore hemodynamic stability after spinal cord injury.Nature medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
75 authors.
Aaron A Phillips *Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. aaron.phillips@ucalgary.ca.ORCID http://orcid.org/0000-0002-7845-1464
Aasta P Gandhi *Defitech Center for Interventional Neurotherapies (NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-6206-6860
Nicolas Hankov *Defitech Center for Interventional Neurotherapies (NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-7112-0091
Sergio D Hernandez-CharpakDefitech Center for Interventional Neurotherapies (NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-0477-8138
Julien RimokDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID http://orcid.org/0000-0002-7078-4758
Anthony V IncognitoDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Anouk E J NijlandDepartment of Research, Sint Maartenskliniek, Nijmegen, the Netherlands.
Marina D'ErcoleONWARD Medical, Lausanne, Switzerland.
Anne WatrinONWARD Medical, Lausanne, Switzerland.
Maxime BerneyDepartment of Nephrology and hypertension, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Aikaterini DamianakiDepartment of Nephrology and hypertension, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-2815-3650
Grégory DumontDefitech Center for Interventional Neurotherapies (NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
Nicolò MacellariDefitech Center for Interventional Neurotherapies (NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID http://orcid.org/0009-0000-7145-0779
Laura De HerdeDefitech Center for Interventional Neurotherapies (NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
Nadine InteringDefitech Center for Interventional Neurotherapies (NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-1741-2178
Donovan SmithDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID http://orcid.org/0000-0001-9632-9326
Ryan MillerDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Meagan N SmithDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID http://orcid.org/0009-0006-2912-6282
Jordan LeeDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID http://orcid.org/0000-0003-3142-5397
Edeny BaakliniDefitech Center for Interventional Neurotherapies (NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-0942-0768
Jean-Baptiste LedouxDepartment of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-0447-5073
Javier G OrdonnezDefitech Center for Interventional Neurotherapies (NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID http://orcid.org/0009-0003-7623-2529
Taylor NewtonFoundation for Research on Information Technologies in Society, Zurich, Switzerland.
Ettore Flavio MeliadòUniversity Medical Center Utrecht, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0003-1240-3141
Léa DuguetONWARD Medical, Lausanne, Switzerland.
Charlotte JacquetONWARD Medical, Lausanne, Switzerland.
Léa Bole-FeysotDefitech Center for Interventional Neurotherapies (NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
Markus RiegerONWARD Medical, Lausanne, Switzerland.
Kristen GelenitisONWARD Medical, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-0208-6971
Yoann DumenyONWARD Medical, Lausanne, Switzerland.
Miroslav CabanONWARD Medical, Lausanne, Switzerland.
Damien GantyONWARD Medical, Lausanne, Switzerland.
Edoardo PaolesONWARD Medical, Lausanne, Switzerland.
Thomas BaumgartnerDepartment of Neurology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Clinical Study Team
Onward Team
Cathal HarteDefitech Center for Interventional Neurotherapies (NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
Charles David SasportesDefitech Center for Interventional Neurotherapies (NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
Paul RomoDepartment of Radiology, University of Calgary, Calgary, Alberta, Canada.
Tristan VougaTWIICE, Lausanne, Switzerland.
Jemina FasolaTWIICE, Lausanne, Switzerland.
Jimmy RavierDefitech Center for Interventional Neurotherapies (NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
Matthieu GautierDefitech Center for Interventional Neurotherapies (NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-4910-8576
Frédéric MerlosDefitech Center for Interventional Neurotherapies (NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
Rik BuschmanMedtronic, Minneapolis, MN, USA.
Tomislav MilekovicDefitech Center for Interventional Neurotherapies (NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-6769-6506
Andreas RowaldDefitech Center for Interventional Neurotherapies (NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-5493-195X
Stefano MandijaUniversity Medical Center Utrecht, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0002-4612-5509
Cornelis A T van den BergUniversity Medical Center Utrecht, Utrecht, the Netherlands.
Niels KusterFoundation for Research on Information Technologies in Society, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-5827-3728
Esra NeufeldFoundation for Research on Information Technologies in Society, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-5528-6147
Etienne PralongDepartment of Neurosurgery, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Lorenz HirtDepartment of Neurology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-2921-5000
Stefano CardaDepartment of Clinical Neuroscience, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Fabio BecceDepartment of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-8444-8504
Etienne AletonDepartment of Clinical Neuroscience, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Kyle RoganDepartment of Anesthesiology, University of Calgary, Calgary, Alberta, Canada.
Patrick SchoettkerDepartment of Anesthesiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Grégoire WuerznerDepartment of Nephrology and hypertension, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Nelleke LangerakDepartment of Research, Sint Maartenskliniek, Nijmegen, the Netherlands.ORCID http://orcid.org/0000-0003-1567-3112
Noël L W KeijsersDepartment of Research, Sint Maartenskliniek, Nijmegen, the Netherlands.
Brian K KwonInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, British Columbia, Canada.
James D GuestDepartment of Neurological Surgery, Miller School of Medicine, Miami, FL, USA.ORCID http://orcid.org/0000-0003-0931-0286
Erika RossONWARD Medical, Lausanne, Switzerland.
John MurphyONWARD Medical, Lausanne, Switzerland.
Erkan KurtDepartment of Neurosurgery, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.
Steve CashaDepartment of Neurosurgery, University of Calgary, Calgary, Alberta, Canada.
Fady GirgisDepartment of Neurosurgery, University of Calgary, Calgary, Alberta, Canada.
Ilse van NesDepartment of Rehabilitation, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID http://orcid.org/0000-0003-3249-3789
Kelly A Larkin-KaiserDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID http://orcid.org/0000-0001-6205-0212
Robin DemesmaekerDefitech Center for Interventional Neurotherapies (NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-0856-0929
Léonie AsbothDefitech Center for Interventional Neurotherapies (NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-2414-9574
Jordan W SquairDefitech Center for Interventional Neurotherapies (NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
Jocelyne BlochDefitech Center for Interventional Neurotherapies (NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland. jocelyne.bloch@chuv.ch.ORCID http://orcid.org/0000-0002-6405-1590
Grégoire CourtineDefitech Center for Interventional Neurotherapies (NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland. gregoire.courtine@epfl.ch.ORCID http://orcid.org/0000-0002-5744-4142
Funding
No grant is acknowledged in the PubMed record.
Abstract
A spinal cord injury (SCI) causes immediate and sustained hemodynamic instability that threatens neurological recovery and impacts quality of life. Here we establish the clinical burden of chronic hypotensive complications due to SCI in 1,479 participants and expose the ineffective treatment of these complications with conservative measures. To address this clinical burden, we developed a purpose-built implantable system based on biomimetic epidural electrical stimulation (EES) of the spinal cord that immediately triggered robust pressor responses. The system durably reduced the severity of hypotensive complications in people with SCI, removed the necessity for conservative treatments, improved quality of life and enabled superior engagement in activities of daily living. Central to the development of this therapy was the head-to-head demonstration in the same participants that EES must target the last three thoracic segments, and not the lumbosacral segments, to achieve the safe and effective regulation of blood pressure in people with SCI. These findings in 14 participants establish the path to designing a pivotal device trial that will evaluate the safety and efficacy of EES to treat the underappreciated, treatment-resistant hypotensive complications due to SCI.
Indexed as
Electric Stimulation TherapyHemodynamicsHypotensionSpinal Cord InjuriesAdultBlood PressureFemaleHumansMaleMiddle AgedProstheses and ImplantsQuality of LifeSpinal Cord
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